The Respiratory Burst and Its Physiological Significance

This series of changes has become known as the respiratory burst. It was first believed that the major function of this respiratory burst was to generate powerful antibacterial agents by the partial reduction of oxygen.

Author: A.J. Sbarra

Publisher: Springer Science & Business Media

ISBN: 9781468454963

Category: Science

Page: 500

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When phagocytes are exposed to a number of different stimuli, they undergo dra matic changes in the way they process oxygen. Oxygen uptake increases markedly, frequently more than 50-fold; the phagocytes begin to produce large quantities of superoxide and hydrogen peroxide; and they immediately begin to metabolize large amounts of glucose by way of the hexose monophosphate shunt. This series of changes has become known as the respiratory burst. It was first believed that the major function of this respiratory burst was to generate powerful antibacterial agents by the partial reduction of oxygen. It is becoming apparent that the respiratory burst has much wider application, and its physiological function in many different biolog ical areas is clear. In this volume, we have attempted to bring together the work of experts who have published extensively on the involvement of the respiratory burst in different physiological functions. In the first three chapters, Dr. Borregaard and Dr. Berton and co-workers and Dr. Roos and co-workers bring together what is known about the respiratory burst. They present up-to-date versions of the biochemical and metabolic activities associ ated with the burst. In Chapter 4, Dr. Styrt and Dr. Klempner discuss the respiratory burst as it affects cellular ion homeostasis. Dr. Cohen and Dr. Britigan (Chapter 5) present some interesting data on the competition between the respiratory burst and bacteria for oxygen. Dr. Dobrina and Dr.

The Respiratory Burst and Its Physiological Significance

This series of changes has become known as the respiratory burst. It was first believed that the major function of this respiratory burst was to generate powerful antibacterial agents by the partial reduction of oxygen.

Author: A.J. Sbarra

Publisher: Springer

ISBN: 0306428830

Category: Science

Page: 500

View: 954

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When phagocytes are exposed to a number of different stimuli, they undergo dra matic changes in the way they process oxygen. Oxygen uptake increases markedly, frequently more than 50-fold; the phagocytes begin to produce large quantities of superoxide and hydrogen peroxide; and they immediately begin to metabolize large amounts of glucose by way of the hexose monophosphate shunt. This series of changes has become known as the respiratory burst. It was first believed that the major function of this respiratory burst was to generate powerful antibacterial agents by the partial reduction of oxygen. It is becoming apparent that the respiratory burst has much wider application, and its physiological function in many different biolog ical areas is clear. In this volume, we have attempted to bring together the work of experts who have published extensively on the involvement of the respiratory burst in different physiological functions. In the first three chapters, Dr. Borregaard and Dr. Berton and co-workers and Dr. Roos and co-workers bring together what is known about the respiratory burst. They present up-to-date versions of the biochemical and metabolic activities associ ated with the burst. In Chapter 4, Dr. Styrt and Dr. Klempner discuss the respiratory burst as it affects cellular ion homeostasis. Dr. Cohen and Dr. Britigan (Chapter 5) present some interesting data on the competition between the respiratory burst and bacteria for oxygen. Dr. Dobrina and Dr.

Biological Oxidation Systems

100-112, Taylor and Francis Ltd., London O'Brien, P.J. (1988) The Respiratory Burst and Its Physiological Significance (Sbarra, A.J., and Strauss, R.R., eds) pp. 203-232, Plenum Press Samoszuk, MK, Gidanian, F., and Rietveld, ...

Author: C.C. Reddy

Publisher: Elsevier

ISBN: 9780323145152

Category: Science

Page: 588

View: 978

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Biological Oxidation Systems, Volume II discusses the various antioxidants and antioxidant enzymes that play significant roles in protecting cells from deleterious reactions between their structural/functional components and the free radicals. This book examines the myriad chemical reactions of a cell’s metabolic activity that produce a variety of free radicals. Comprised of three parts encompassing 35 chapters, this volume starts with an overview of the metabolism of xenobiotics during arachidonic acid metabolism. This book then discusses the various causes of human cancers and diseases, which include exposure to environmental chemicals and other toxicants. This text considers the dietary habits and nutritional factors that play an important role in the causation and development of several human cancers, including cancer of the breast, colon, prostate, and other organs. Other chapters discuss the toxic effects of several xenobiotics that involve free-radical mechanisms. Biochemists, biophysicists, microbiologists, organic chemists, food chemists, and medical scientists will find this book extremely useful.

Biological Reactive Intermediates IV

Oxidants formed by the respiratory burst: their physiological role and their involvement in the oxidative metabolism and activation of drugs. The Respiratory Burst and Its Physiological Significance (Sbarra, A.J., and Strauss, R.R., ...

Author: Charlotte M. Witmer

Publisher: Springer Science & Business Media

ISBN: 9781468458770

Category: Medical

Page: 912

View: 776

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The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.

Free Radical Mechanisms of Tissue Injury

Sbarra , A. J. and Strauss , R. R. , Eds . , The Respiratory Burst and Its Physiological Significance , Plenum Press , New York , 1988 . 4. Brain , J. D. , Toxicological aspects of alteration of pulmonary macrophage function , Annu .

Author: Mary Treinen Moslen

Publisher: CRC Press

ISBN: 0849351618

Category: Science

Page: 240

View: 966

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This timely volume describes the contributions of free radicals and reactive oxygen species to disease processes in a variety of tissues. Topics include the roles of lipid peroxide-modified lipoproteins in atherosclerosis, peroxidation products in retinopathy, reactive oxygen species and neutrophils in mycardial ischemia-reflow injury, iron and reactive oxygen species in hemoglobin-mediated CNS damage and in asbestos-mediated lung injury. Critical reviews examine the evidence for radical species in ethanol-induced liver injury and in muscular dystrophy. The wealth of new information presented makes this book valuable for teaching and an important reference volume for researchers exploring problems in human disease.

N Oxidation of Drugs

O'Brien, P.J. (1988b) Oxidants formed by the respiratory burst: their physiological role and their involvement in the oxidative metabolism and activation of drugs, in The Respiratory Burst and Its Physiological Significance (eds A.J. ...

Author: P. Hlavica

Publisher: Springer Science & Business Media

ISBN: 9789401131124

Category: Medical

Page: 487

View: 496

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Biochemistry and Physiology of the Neutrophil

This book provides an up-to-date review of the role of the neutrophil in infection and inflammation.

Author: Steven W. Edwards

Publisher: Cambridge University Press

ISBN: 9780521416986

Category: Medical

Page: 299

View: 648

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This book provides an up-to-date review of the role of the neutrophil in infection and inflammation.

Luminescence Biotechnology

... S., and Bellavite, P., The respiratory burst of phagocytes, in The Respiratory Burst and Its Physiological Significance, ... Badwey, J. A. and Karnovesky, K. L., Active oxygen species and the function of phagocytic leucocytes, Annu.

Author: Knox Van Dyke

Publisher: CRC Press

ISBN: 9781420041804

Category: Science

Page: 624

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The dangers and drawbacks inherent in radioactivity-based methods along with a demonstrated and dramatic increase in sensitivity have precipitated a major shift towards luminescence measurements and visualization techniques. Their use has now spread even to traditional clinical environments, and their applications have grown from clinical assays to DNA sequencing, antioxidant detection, and high-throughput screening. Luminescence Biotechnology: Instruments and Applications furnishes a thorough w review of the principles and applications of luminescence. With a consistent focus on practical considerations, contributions from a team of internationally acclaimed authors take you from the fundamentals of the different luminescence-based assay systems, calculation methods, and instruments through the spectrum of applications and latest research advances. Topics include gene and protein assays, oxidative stress and tissue aging, applications of luminescent microspheres, and proton image analysis. This book clearly identifies the advantages of luminescence over other assay techniques, discusses its potential pitfalls, and illustrates the broad range of its utility. Whether you are a newcomer to the field or a seasoned professional, this book provides a wealth of information that will bring you quickly up to date on the technology, recent research developments, and cutting-edge applications.

Advances in Clinical Chemistry

Zgliczynski, M. J., and Stelmaszynska, T., The respiratory burst of neutrophilic granulocytees and its influence on infected tissues. In “Respiratory Burst and Its Physiological Significance,” pp. 315–347. Plenum Press, New York, 1972.

Author:

Publisher: Elsevier

ISBN: 0080522300

Category: Science

Page: 342

View: 902

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For more than thirty years, this serial has broadened the technical scope and expanded the scientific base of clinical chemistry. These volumes clarify the areas of molecular biology, informatics, and the monitoring of physiological parameters in critical situations as they pertain to clinical chemistry. Each volume of Advances in Clinical Chemistry contains an index, and each chapter includes references.

Current Catalog

1951Haugaard , Jeffrey J. , see The Respiratory burst and its physiological significance / edited by Anthony J. Sbarra and Robert R. Strauss . New York : Plenum Press , c1988 . xxi , 476 p . : ill . Includes bibliographies and index .

Author: National Library of Medicine (U.S.)

Publisher:

ISBN: UOM:39015046741230

Category: Medicine

Page:

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First multi-year cumulation covers six years: 1965-70.