Jak Stat Signaling From Basics to Disease

Cytokine receptorJak signal a b U-Stat dimer (antiparallel conformation Canonical P-Statpathway STATSTAT P-Stat dimers (parallel conformation) U -Stat syn thes is Nuclear P-Stat dimers Nuclear U-Stat dimers Posttranslational ...

Author: Thomas Decker

Publisher: Springer Science & Business Media

ISBN: 9783709108918

Category: Science

Page: 450

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JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

STAT Inhibitors in Cancer

Loss of expression or function of these phosphatases or other inhibitors of the JAK/STAT pathway can lead to constitutive activation of STAT proteins and contribute to the malignant phenotype [6, 19, 23–25]. Among the STAT pathway ...

Author: Alister C. Ward

Publisher: Springer

ISBN: 9783319429496

Category: Medical

Page: 195

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This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.

JAK STAT Pathway in Disease

inflammation of the intestine, suggesting that STAT-3 activation in cells other than macrophages are responsible for the inflammatory reaction.40 One also has to bear in mind, that the antiinflammatory cytokines IL-10 is also able to ...

Author: Jr., Richard H. Bell

Publisher: CRC Press

ISBN: 9781498713764

Category: Medical

Page: 190

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This book reviews current understanding of the biological roles of the signal transducer and activator of transcription (STAT) proteins and their dysregulation in diseases. STAT proteins were named after their role as signal transducers and activators of transcription. STAT proteins are highly conserved among species, thus reflecting the importance

JAK STAT Signaling in Diseases

FIGURE 13.1 JAK-STAT signaling cascade. (1) Cytokine-receptor interaction and receptor dimerization (2) transactivation of receptor-associated JAKs (3) JAK phosphorylation of receptor (4) STAT binds phosphorylated receptor and is ...

Author: Ritobrata Goswami

Publisher: CRC Press

ISBN: 9781351042444

Category: Medical

Page: 290

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JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.

The Jak Stat Pathway in Hematopoiesis and Disease

86 Nevertheless , a distinction can be made between the effects of inhibiting Stats in an animal in which ... A preponderance of evidence would suggest that Stat inhibition will lead to inhibition of tumor cell survival and / or ...

Author: Alister C. Ward

Publisher: Springer Science & Business Media

ISBN: 0306474247

Category: Science

Page: 140

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This book for the first time comprehensively surveys the research investigating the Jak-Stat pathway and its role in normal blood development as well as its perturbation in disease. It draws on the expertise of world-renowned medical researchers to take the reader from basic biology through to recent therapeutic advances.

Hockey Abstract Presents Stat Shot

years, and word posts about some particular newly developed stat, getting to the bottom where they lay out the results for certain key players, and then thinking “Wait, is a high number supposed to be good or bad?

Author: Vollman, Rob

Publisher: ECW Press

ISBN: 9781770909236

Category: Sports & Recreation

Page: 360

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Making advanced stats simple, practical, and fun for hockey fans Advanced stats give hockeyÍs powerbrokers an edge, and now fans can get in on the action. Stat Shot is a fun and informative guide hockey fans can use to understand and enjoy what analytics says about team building, a playerÍs junior numbers, measuring faceoff success, recording save percentage, the most one-sided trades in history, and everything you ever wanted to know about shot-based metrics. Acting as an invaluable supplement to traditional analysis, Stat Shot can be used to test the validity of conventional wisdom, and to gain insight into what teams are doing behind the scenes „ or maybe what they should be doing. Whether looking for a reference for leading-edge research and hard-to-find statistical data, or for passionate and engaging storytelling, Stat Shot belongs on every serious hockey fanÍs bookshelf.

The Canada Cup of Hockey Fact and Stat Book

1987 Canada Cup: Player Statistics Canada Player Stats NAME GP G A Pts +/- PIM PPG SHG GWG Wayne Gretzky 9 3 18 21 -2 2 1 O 0 Mario Lemieux 9 1 1 7 18 5 8 5 O 4 Raymond Bourque 9 2 6 8 3 10 2 O 0 Larry Murphy 8 1 6 7 8 4 1 O 0 Mark ...

Author: H.J. Anderson

Publisher: Trafford Publishing

ISBN: 9781412055123

Category:

Page: 186

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The Canada Cup gave us some the greatest games and never to be forgotten moments in hockey history. Re-live some of those moments with this fascinating insight into the tournament.

Law Creating Public Utilities Commission of the District of Columbia 37 Stat 974 Approved March 4 1913 Corrected to March 1 1930

... approved March 3 , 1915 ( 38 U. S. Stats . p . 900 ) . * * * * Free transportation . Policemen and firemen . “ The several street railway companies in the District of Columbia are authorized and required to transport free of charge ...

Author: United States. District of Columbia

Publisher:

ISBN: STANFORD:36105211297143

Category:

Page: 60

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Federal Legislative Histories

1085 N/A N/A 65 Stat. 648 66 Stat. 328 66 Stat. 792 66 Stat. 792 67 Stat. 588 68 Stat. 454 68 Stat. 666 68A Stat. 3 68A Stat. 3 68 Stat. 919 68 Stat. 919 69 Stat. 695 N/A 72 Stat. 731 72 Stat. 997 73 Stat. 519 73 Stat. 519 75 Stat.

Author: Survey Research Consultants International, Inc. Staff

Publisher: Greenwood

ISBN: UOM:49015002887256

Category: Law

Page: 595

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This first annotated bibliography dealing with U.S. federal legislative history covers both Congressional, executive agency, and special commission sources published from 1862 through 1990. The 257 entries provide information about the scope and content of the documents, the locations, the titles and popular names of the bills and laws, the publication dates, the author, the LC card number, the OCLC number, the SUDoc number, the CIS number, the UPA citation, and other information about relevant bills. Information is given about the specific sources and types of sources in the Congress, the Congressional Research Service, and the executive agencies. The annotations describe the types of documentation covered in a work, provide notes about citations and the pagination of original documents, and refer to the location of texts in the Statutes at Large. Author, popular name, Congressional session, public law number, and bill number indexes also make this landmark guide easily accessible for students, teachers, and government staff to use in conducting research into the vast treasury of historical data beginning with the laws in 1796 (4th Congress) through 1990 (101st Congress).

United States Code Annotated

_ _ 94 Sixt 3042 94 Slat 3043 94 Stat 3050 94 Stat 3063 94 Slat 3080 94 Stat 3081 9-1 Stat 3(lî1 94 Stat 3081 94 Slat 3081 94 Stat 3081 94 Star 3082 94 Stat 3083 94 Stat 3084 94 Stat 3084 94 Sta13091 94 Sun 3035 94 Stan 3086 94 Stat.

Author: United States

Publisher:

ISBN: UOM:35112204442109

Category: Law

Page:

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Comprising all laws of a general and permanent nature under arrangement of official code of the laws of the United States, with annotations from federal and state courts.

Official Opinions of the Attorneys General of the United States Advising the President and Heads of Departments in Relation to Their Official Duties

14 ( 23 Stat . , 57 ) . 1884 , June 26 , sec . 20 ( 23 Stat . , 58 ) 1884 , July 5 , secs . 3 and 4 ( 23 Stat . , 115 ) . 1885 , February 26 ( 2 : 3 Stat . , 332 ) 1886 , June 19 , ser . 11 ( 24 Stat . , 81 ) 1888 , September 13 ...

Author: United States. Department of Justice

Publisher:

ISBN: OSU:32437000654372

Category: Administrative law

Page:

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The federal reporter

2d 467 14 — 300 So . 2d 183 14 , § 1 - 526 P . 2d 402 26 - 513 S . W . 2d 346 26 — 513 S . W . 2d 442 1964 , Sept . 2 , P . L . 88 – 563 , $ 2 ( a ) , 78 Stat . 809 — 501 F . 2d 311 1968 , April 11 , P . L . 90 – 281 , $ 406 , 82 Stat .

Author:

Publisher:

ISBN: UCAL:B4441556

Category:

Page:

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Public Affairs Bulletin

1936, 11 Item Number April 16 (L9 Stat. 1210 $), (2) (e) (f)) — — — — =TF May 15 (L9 Stat. 1292 (2)) — — — — — — — — — — — — lu2 May 27 (19 Stat. 1387 c. 165) — — — — — — — — — — — lh2 June 19 (19 Stat. 1535 c.

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ISBN: UCLA:31158009039503

Category:

Page:

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Report of the Royal Commission on the Poor Laws and Relief of Distress

Thriftless and improvident persons, for (M. L. Baker), Stat., App. XIX. (5) ; (J. HaUet), Stat., App. XLII. (3); (W. K. Mundy), Stat., App. LXIV. (9) ; (J. M. Read), Stat., App. LXXIII. (6) ; (D. Ross), Stat., App. LXXVI.

Author: Great Britain. Royal Commission on Poor Laws and Relief of Distress

Publisher:

ISBN: MINN:319510023489117

Category: Poor

Page:

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Supreme Court Reporter

310, $ 20, 36 Stat. 569–520 P.2d 319 1910, June 25, ch. 431, § 23, 36 Stat. 861–94 S.Ct. 2474 1913, Dec. 23, ch. 6, § 16, 38 Stat. 265–215 N.W.2d 166 1914, Oct. 15, ch. 323, § 7, 38 Stat. 731. Amended 1950, Dec. 29, ch. 1184, 64 Stat.

Author: United States. Supreme Court

Publisher:

ISBN: STANFORD:36105060125098

Category: Law reports, digests, etc

Page:

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The Complete Statutes of England Classified and Annotated

PAG- Stat. (1344) 18 Edw. 3, stat. 3, c. I (Bishops exempt from Secular Jurisdiction) ______ 163 The Statute of Provisors, 1350-1 (25 Edw. 3, stat. 4) - - - - 311 Stat. (1351-2) 25 Edw. 3, stat. 6 (Ordinance for the Clergy) - - - 319 ...

Author: Great Britain

Publisher:

ISBN: STANFORD:36105062531061

Category: Law

Page:

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United States Congressional Serial Set

201(9) (88 Stat. 323) .. BAA, § 313(d)(3) (94 Stat. 312). . Pub. L. 93—344, 1012(3)... . Pub. L. 934344, 1013(a)... . Pub. L. 93-344, 1014(c) ......... .. Feb. 20. 1946. ch. 33. § 3(a) (92 Stat. 1892; 93 Stat. 24). Feb. 20. 1946, ch.

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Publisher:

ISBN: UOM:39015087617190

Category: United States

Page:

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Municipal Register

311; Stat. 1907, Chap. 560, § 78; Rev. Ord. 1898, Chap. 15; C. C, Title IV., Chap. 16; Stat. 1909, Chap. 486, §§ 53-61 Stat. 1910, Chap. 520; Stat. 1911, Chaps. 304, 469, 517, 550, 735 Stat. 1912, Chaps. 275, 471, 483, 641; Stat.

Author: Boston (Mass.)

Publisher:

ISBN: STANFORD:36105122907442

Category: Boston (Mass.)

Page:

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Containing a register of the city government ... with lists of executive and other public officers and membership of former city governments.

Pamphlets on Forestry

Territories , share of forest receipts , paid by Secretary of Treasury ( 34 Stat . L. , 251 ) .. 118 Timber and stone lands , canceled entries , decision . 70 cutting and removal , forest reservations ( 31 Stat . L. , 661 ) .

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Publisher:

ISBN: UCAL:$B11551

Category: Forests and forestry

Page:

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