Starling s Law of The Heart Revisited

Frankl measured the isovolumic pressure developed by frog heart at different volumes. He therefore discovered the pressure-volume-volume rela tionship which depends directly on the force-length relationship of the 2 sarcomeres.

Author: H. E. D. J. Keurs (III.)

Publisher: Springer

ISBN: UOM:39015013214468

Category: Medical

Page: 172

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H. E. D. J. TER KEURS & M. I. M. NOBLE The "Starling's Law of the Heart" and "The Frank-Starling Mechanism" have long been the cornerstone of cardiac mechanical physiology. It is often forgotten that Frank and Starling carried out fundamentally different exper iments. Frankl measured the isovolumic pressure developed by frog heart at different volumes. He therefore discovered the pressure-volume-volume rela tionship which depends directly on the force-length relationship of the 2 sarcomeres. Starling ,3 studied cardiac shortening as manifest by cardiac output and its relationship to end-diastolic conditions as manifest by right atrial pressure. Thus he was studying the ability of cardiac muscle to shorten more at a given load from a greater initial length. Starling in the promulga 4 tions of his law implied a common mechanism for these two phenomena and spoke of the "energy liberated" being a function of initial muscle fiber length. However, there has been much confusion about the interrelationship between the two different aspects studied by Frank and Starling. The 1960s saw the era of isolated cardiac muscle mechanics, beginning with 5 the paper of Abbott and Mommaerts. Whole muscle length-tension relations were equated with sarcomere-length-tension relations by fixation of muscle at a particular point on the curve and determination of sarcomere length by electronmicroscopy.

Starling s Law of The Heart Revisited

H.E.D.J. TER KEURS & M.I.M. NOBLE The “Starling's Law of the Heart” and “The Frank-Starling Mechanism” have long been the cornerstone of cardiac mechanical physiology. It is often forgotten that Frank and Starling carried out ...

Author: Henk Keurs

Publisher: Springer Science & Business Media

ISBN: 9789400913134

Category: Medical

Page: 168

View: 140

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H. E. D. J. TER KEURS & M. I. M. NOBLE The "Starling's Law of the Heart" and "The Frank-Starling Mechanism" have long been the cornerstone of cardiac mechanical physiology. It is often forgotten that Frank and Starling carried out fundamentally different exper iments. Frankl measured the isovolumic pressure developed by frog heart at different volumes. He therefore discovered the pressure-volume-volume rela tionship which depends directly on the force-length relationship of the 2 sarcomeres. Starling ,3 studied cardiac shortening as manifest by cardiac output and its relationship to end-diastolic conditions as manifest by right atrial pressure. Thus he was studying the ability of cardiac muscle to shorten more at a given load from a greater initial length. Starling in the promulga 4 tions of his law implied a common mechanism for these two phenomena and spoke of the "energy liberated" being a function of initial muscle fiber length. However, there has been much confusion about the interrelationship between the two different aspects studied by Frank and Starling. The 1960s saw the era of isolated cardiac muscle mechanics, beginning with 5 the paper of Abbott and Mommaerts. Whole muscle length-tension relations were equated with sarcomere-length-tension relations by fixation of muscle at a particular point on the curve and determination of sarcomere length by electronmicroscopy.

Systolic and Diastolic Function of the Heart

H.E.D.L. ter Keurs and M.I.M. Noble ( Eds ) , Starling's Law of the Heart Revisited . Kluwer Academic Publishers , Dordrecht , 1988 . D.D. Glower et al . , Linearity of the Frank - Starling relationship in the intact heart : the concept ...

Author: Neil B. Ingels

Publisher: IOS Press

ISBN: 9051992114

Category: Medical

Page: 462

View: 421

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Chapter 22: Crossbridge and Muscle Properties, Energetics, and Pressure-Volume Area -- Chapter 23: Constancy and Variability of Oxygen Costs of Mechanical Energy (PVA) and Contractility (Emax) -- Chapter 24: Tight Coupling between Regional Myocardial Oxygen Consumption and Contractile Function -- Chapter 25: Force-Frequency Relation, Force-Interval Relation, and Mechanical Restitution -- Chapter 26: Elastance-Based Mechanical Restitution Provides Data from the Intact Heart Not Available from Any Other Technique -- Chapter 27: Contractility Indices -- Chapter 28: Searching for Indices of Contractility Is Counterproductive -- Chapter 29: Rapid Contractile Upregulation Rematches Stroke Work to Increased Afterload Independent of Ventricular Geometry, Afterload-Related Coronary Perfusion Pressure Fluctuations and Baseline Contractile State -- Chapter 30: Wall Thickening, Shears, and Cleavage Planes -- Chapter 31: Mechanisms of Large Ventricular Wall Shortening and Thickening -- Chapter 32: Twisting, Torsion, and Other Shears -- Chapter 33: Ventricular Twist and Its Relationship to Pressure Volume and Shortening -- Chapter 34: Differences in Systolic and Diastolic Torsional Deformation of the Left Ventricle -- Chapter 35: Coronary Flow, Systolic Perfusion, and the "Gregg Phenomenon -- Chapter 36: Intramyocardial Hydraulic Regulation of Cardiac Mechanics and Energetics -- Chapter 37: Left Ventricular Afterload and Arterial Coupling -- Indexes -- Author Index -- Affiliation Index -- Subject Index

An Introduction to Cardiovascular Physiology

6.11 Summary Stroke volume is controlled primarily by filling pressure via the Frank—Starling mechanism and by ... New York te Keurs, H. E. D. J. and Noble, M. I. M. (1988) Starling's Law of the Heart Revisited, Kluwer Academic, ...

Author: J R Levick

Publisher: Butterworth-Heinemann

ISBN: 9781483183848

Category: Medical

Page: 288

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An Introduction to Cardiovascular Physiology is designed primarily for students of medicine and physiology. This introductory text is mostly didactic in teaching style and it attempts to show that knowledge of the circulatory system is derived from experimental observations. This book is organized into 15 chapters. The chapters provide a fuller account of microvascular physiology to reflect the explosion of microvascular research and include a discussion of the fundamental function of the cardiovascular system involving the transfer of nutrients from plasma to the tissue. They also cover major advances in cardiovascular physiology including biochemical events underlying Starling's law of the heart, nonadrenergic, non-cholinergic neurotransmission, the discovery of new vasoactive substances produced by endothelium and the novel concepts on the organization of the central nervous control of the circulation. This book is intended to medicine and physiology students.

Update 1991

Blackwell, Oxford ter Keurs HEDJ, Noble MIM (1988) Starling's law of the heart revisited. Kluwer Academic Publishers, Dordrecht . Noble MIM (1988) Cardiovascular response to fluid loading. Bailliere's Clinical Anaesthesiology 2:483-487 ...

Author: Jean L. Vincent

Publisher: Springer Science & Business Media

ISBN: 9783642844232

Category: Medical

Page: 597

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A comprehensive survey of recent advances is given in this Update. The wide spectrum of experimental and clinical investigations include the pathophysiologic, diagnostic and therapeutic aspects.

Molecular Control Mechanisms in Striated Muscle Contraction

(1988) Starling's Law of the Heart Revisited Kluwer Academic Publishers, Dordrecht. ter Keurs, H.E.D.J., ... Tobacman, L.S. and Lee, R. (1987) Isolation and functional comparison of bovine cardiac troponin T isoforms, J. Biol. Chem.

Author: R.J. Solaro

Publisher: Springer Science & Business Media

ISBN: 9789401599269

Category: Medical

Page: 468

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Molecular Control Mechanisms in Striated Muscle Contraction addresses the molecular mechanisms by which contraction of heart and skeletal muscles is regulated, as well as the modulation of these mechanisms by important (patho)physiological variables such as ionic composition of the myoplasm and phosphorylations of contractile and regulatory proteins. For the novice, this volume includes chapters that summarize current understanding of excitation-contraction coupling in striated muscles, as well as the compositions and structures myofibrillar thick and thin filaments. For the expert, this volume presents detailed pictures of current understanding of the mechanisms underlying the CA2+ regulation of contraction in heart and skeletal muscles and discusses important directions for future investigation.

Electromagnetism Quanta And Electron Flow In The Electrophysiology Of Living Cells

The Cardiovascular System in Health and Disease ISBN: 978-1-86094-278-5 Other Titles by the Author The Cardiac Cycle Cardiac Metabolism Starling's Law of the Heart Revisited The Interval-Force Relationship of the Heart: Bowditch ...

Author: Mark Noble

Publisher: World Scientific

ISBN: 9789811234965

Category: Science

Page: 220

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Electrons are involved in all electrical phenomena, and living cells cannot be an exception. This book takes on a decidedly different approach to existing texts on electrophysiology, by considering electrical physiological processes from the viewpoint of electron flow, rather than the conventional notion of ion movement. It concisely describes the theoretical background of electron density and cellular voltage, before exploring thought-provoking questions such as the relationship between electrolyte distribution and transmembrane potential, and the source of electricity generation in living cells. A new electromagnetic theory of muscular function is presented, and all topics of relevance — including the electrophysiology of invertebrates, plants, fungi and bacteria — are comprehensively covered. Using plain language and more than 40 original illustrations, the author has designed each chapter to provide a succinct overview of an individual topic in a format that appeals to both the expert and the uninitiated. Electromagnetism, Quanta, and Electron Flow in the Electrophysiology of Living Cells proffers a refreshingly new way to understand a fascinatingly old subject.

Wrong Notions About the Heart

ter Keurs, HEDJ, Noble MIM (1988) Starling's Law of the Heart Revisited. Kluwer Academic Publishers, Dordrecht. West BJ. (2006). Where medicine went wrong. Studies of nonlinear phenomena in life science, Volume 11:ISBN: 978981256883 ...

Author: Mark Noble

Publisher: Lulu Press, Inc

ISBN: 9781483415628

Category: Health & Fitness

Page:

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Grumpy old retired Prof of Medicine rails (with cartoons) against low salt and low fat diets, over-diagnosis of high blood pressure, inappropriate use of anti-coagulants, etc. For light relief, some unsolved puzzles of body function are discussed.

Chronic Obstructive Pulmonary Disease

Noble, M.I.M. (1988) The pressure-volume relationship of the intact heart, in Starling's Law of the Heart Revisited, (eds H.E.D.J. ter Keurs and M.I.M. Noble), Kluwer, Dordrecht, pp. 126. Redington, A.N., Gray, H.H. and Hodson, ...

Author: P. M. A. Calverley

Publisher: Springer

ISBN: 9781489945259

Category: Medical

Page: 579

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Electrocardiography and Cardiac Drug Therapy

ISBN 0-89838-380-3. Ter Keurs, H.E.D.J., Noble, M.I.M., eds.: Starling's law of the heart revisited. 1988. ISBN 0-89838-382-X. Sperelakis, N., ed.: Physiology and pathophysiology of the heart. 1988. ISBN 0-89838-388-9 De Jong, J.W., ed.

Author: Vinzenz Hombach

Publisher: Springer Science & Business Media

ISBN: 9789400910812

Category: Medical

Page: 385

View: 860

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This book is a comprehensive overview of electrocardiography and the major effects of current cardiac pharmacological therapy on electrocardiography. The text is based on work presented at the International Symposium on Non-invasive Cardiovascular Diagnosis and Therapy, held in May, 1987 at the University of Cologne. The theme of the book is to review, in broad clinical perspective the current state-of-the-art of electrocardiography as it pertains to standard electrocar diograms, exercise testing, ambulatory electrocardiography, electrocardiographic telemetry, and high resolution electrocardiography. Furthermore, advance!, in cardiac drug therapy in relation to diuretics, beta blocking drugs, antiarrhythmic agents and thrombolytic agents are reviewed. The emphasis of the conference and this book is to review the clinical state-of-the-art information and applications in this regard. In the initial section on electrocardiography, Dr. Spodick reviews our present day physiologic and pathophysiologic understanding of systolic time intervals, and how they are affected by a variety of cardiac disease states and pharmacologic agents. Dr. Ellestad examines problems and provides pragmatic tips on exercise testing in the diagnosis of coronary artery disease, and advances in exercise scores and computer analysis. Dr. Graboys reviews the value of exercise testing in the diagnosis and management of patients with serious ventricular arrhythmias. Dr. Kellermann presents the complimentary role that exercise testing plays in com prehensive follow-up therapy of the cardiac patient, and the use of exercise for work and physical training. Detailed information concerning the interaction of cardiac rehabilitation and ventricular arrhythmias are examined.