Spontaneous Pathology of the Laboratory Non Human Primate

Spontaneous Pathology of the Laboratory Non-human Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies.

Author: Alys E. Bradley

Publisher: Academic Press

ISBN: 9780128130896

Category: Science

Page: 575

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Spontaneous Pathology of the Laboratory Nonhuman Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research. Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors. Contains color illustrations that depict the most common lesions to augment descriptions Covers descriptions that are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP) Provides pathologists with common terms that are compliant with the FDA’s Standard for Exchange of Nonclinical Data (SEND) guidelines

Spontaneous Pathology of the Laboratory Rabbit

The book provides a comprehensive text on the spontaneous pathology seen in common laboratory rabbit strains. This is the first book collating information on all organ systems in these strains.

Author: Alys Bradley

Publisher: Academic Press

ISBN: 0128225289

Category: Science

Page: 575

View: 385

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Provides a comprehensive text describing the spontaneous pathology seen in the common laboratory rabbit strains. This is the first book collating information on all organ systems in these strains. Rabbits are widely used for experimentation and testing mainly due to practical, rather than scientific, considerations. They are small and usually docile, easily restrained, cheap to maintain, and breed prodigious. Spontaneous Pathology of the Laboratory Rabbit serves as a "go to” text for all pathologists working on laboratory rabbits in safety assessment studies, and to help diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets. Consist of multi-author chapters arranged by Organ systems Provides color illustrations that depict the most common lesions to augment the descriptions provides pathologists with common terms that are compliant with the FDA's Standard for Exchange of Nonclinical Data (SEND) guidelines Gives references for recommended tissue trimming planes

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

Spontaneous lesions of the cardiovascular system in purpose-bred laboratory nonhuman primates. ... Kaspareit J, Friderichs-Gromoll S, Buse E, Habermann G. Background pathology of the common marmoset (Callithrix jacchus) in toxicological ...

Author: Joerg Bluemel

Publisher: Academic Press

ISBN: 9780124171466

Category: Medical

Page: 716

View: 162

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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Haschek and Rousseaux s Handbook of Toxicologic Pathology

Nonhuman. Primates. Incidental (not commonly reported) or background findings (known to occur in the species) in NHPs ... compiled into “Spontaneous Pathology of the Laboratory Non-Human Primate,” Bradley and Chilton, eds., (in press).

Author: Wanda M. Haschek

Publisher: Academic Press

ISBN: 9780128218297

Category: Medical

Page: 1152

View: 435

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Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 1 of the Fourth Edition covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Completely revised with a number of new chapters, Volume 1 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Nonhuman Primates

Preface This book on nonhuman primate pathology is the 12th volume of a set of monographs prepared under the ... or identity, with a human counterpart and second, the necessity to differentiate lesions of spontaneous disease from those ...

Author: Thomas C. Jones

Publisher: Springer Science & Business Media

ISBN: 9783642849244

Category: Medical

Page: 248

View: 994

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The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The M on ographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stud ies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book on nonhuman primate pathology is the 12th volume of a set of monographs prepared under the sponsorship of the International Life Sciences Institute (ILSI).

Conn s Handbook of Models for Human Aging

Spontaneous neoplasms observed in cynomolgus monkeys (Macaca fascicularis) during a 15-year period. ... The prostate of the nonhuman primate: normal anatomy and pathology. ... In: Fox, E.A. (Ed.), Laboratory Animal Medicine (Chapter ...

Author: Jeffrey L. Ram

Publisher: Academic Press

ISBN: 9780128113547

Category: Medical

Page: 1218

View: 110

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Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

Nonhuman Primates in Biomedical Research

Diseases Christian R. Abee, Keith Mansfield, Suzette D. Tardif, Timothy Morris ... As in human primates, this disease is not limited to females. ... Spontaneous primary carcinoma of the prostate in a monkey (Macaca mulatta).

Author: Christian R. Abee

Publisher: Academic Press

ISBN: 9780123813664

Category: Medical

Page: 868

View: 635

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The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

The Laboratory Primate

However, since the phylogenetic relationship between animals and humans is not linear but branching, leading to genetic ... Some of these, such as ageing diseases, may be spontaneous in non-human primates while others may be induced.

Author:

Publisher: Elsevier

ISBN: 008045416X

Category: Science

Page: 650

View: 520

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A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included. Two-color, user-friendly format, with copious illustrations and color plates Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques