Peripheral Neuropathy in Childhood

A liberally illustrated and fully updated new edition of this very practical text.

Author: Robert A. Ouvrier

Publisher: Cambridge University Press

ISBN: 1898683174

Category: Medical

Page: 335

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A liberally illustrated and fully updated new edition of this very practical text.

Peripheral Neuropathy in Childhood

A review of the literature on peripheral neuropathy in children published over the last century in light of the clinical experiences of practitioners at the Children's Hospital (Sidney) and the U. of Sidney, Australia.

Author: Robert A. Ouvrier

Publisher:

ISBN: 0608058734

Category:

Page: 251

View: 703

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Peripheral Nerve Disorders

Hereditary neuropathies (HN) with onset in childhood are categorized according to clinical presentation, pathogenic mechanism based on electrophysiology, genetic transmission and, in selected cases, pathological findings.

Author: Pierre Landrieu

Publisher: Elsevier Inc. Chapters

ISBN: 9780128078808

Category: Medical

Page: 1008

View: 242

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Hereditary neuropathies (HN) with onset in childhood are categorized according to clinical presentation, pathogenic mechanism based on electrophysiology, genetic transmission and, in selected cases, pathological findings. Especially relevant to pediatrics are the items “secondary” versus “primary” neuropathy, “syndromic versus nonsyndromic,” and “period of life.” Different combinations of these parameters frequently point toward specific monogenic disorders. Ruling out a neuropathy secondary to a generalized metabolic disorder remains the first concern in pediatrics. As a rule, metabolic diseases include additional, orienting symptoms or signs, and their biochemical diagnosis is based on logical algorithms. Primary, motor sensory are the most frequent HN and are dominated by demyelinating autosomal dominant (AD) forms (CMT1). Other forms include demyelinating autosomal recessive (AR) forms, axonal AD/AR forms, and forms with “intermediate” electrophysiological phenotype. Peripheral motor neuron disorders are dominated by AR SMN-linked spinal muscular atrophies. (Distal) hereditary motor neuropathies represent 40 genes with various biological functions have been found to be responsible for primary HN. Many are responsible for various phenotypes, including some without the polyneuropathic trait, and some for various types of transmission.

Textbook of Peripheral Neuropathy

INTRODUCTION Peripheral neuropathies (PNs) in childhood are a highly heterogeneous group of disorders. Childhood neuropa— thies share some similarity to their adult counterparts; however, the differential diagnosis, ...

Author: Peter D. Donofrio

Publisher: Demos Medical Publishing

ISBN: 9781936287109

Category: Medical

Page: 475

View: 923

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Textbook of Peripheral Neuropathy is a practical but complete reference for neurologists in general practice who are evaluating patients with peripheral neuropathy. The book covers a broad range of neuropathies including mononeuropathy, mononeuritis multiplex, and polyneuropathy (which accounts for the greatest number of cases) and provides an evidence-based approach to testing, diagnosis, and treatment. The chapters are written by internationally renowned expert contributors with deep clinical experience and contain numerous tables, figures, and algorithms for quick access to key information. The book covers both inherited and acquired diseases, including neuropathies arising from physical injury, diabetes, alcoholism, toxins, autoimmune responses, nutritional deficiencies, vascular and metabolic disorders, medication-induced neuropathies, and idiopathic conditions.

Neuromuscular Disorders of Infancy Childhood and Adolescence

In children, the prevalence of hereditary peripheral neuropathy (Charcot-Marie-Tooth disease) is approximately 0.2%,1 with hereditary neuropathies accounting for 30 to 70% of all cases of pediatric peripheral nerve disease.2,3 Among ...

Author: Basil T. Darras

Publisher: Elsevier

ISBN: 9780124171275

Category: Medical

Page: 1160

View: 858

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Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science, diagnosis and treatment of neuromuscular disorders in childhood is a timely and needed resource for all clinicians and researchers studying neuromuscular disorders, especially in childhood. The Second Edition is completely revised to remain current with advances in the field and to insure this remains the standard reference for clinical neurologists and clinical research neurologists. The Second Edition retains comprehensive coverage while shortening the total chapter count to be an even more manageable and effective reference. Carefully revised new edition of the classic reference on neuromuscular disorders in infancy, childhood and adolescence. Definitive coverage of the basic science of neuromuscular disease and the latest diagnosis and treatment best practices. Includes coverage of clinical phenomenology, electrophysiology, histopathology, molecular genetics and protein chemistry

Evaluation of Peripheral Neuropathy Among Childhood Cancer Patients

The results of the scoping review identified two valid and reliable measures (i.e., Ped-mTNS, mTNS©-PV), with one tool better suited for children (mTNS©-PV).

Author: Deborah Lee

Publisher:

ISBN: 9798662399990

Category: Electronic dissertations

Page: 216

View: 529

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The principal toxicity for children who receive vincristine for the treatment of acute lymphocytic leukemia (ALL) is peripheral neuropathy, with symptoms that negatively affect physical function and may require the reduction or withdrawal of chemotherapy; even though cumulative dosing has not been shown to increase peripheral neuropathy. This population not only has to deal with the physical challenges of cancer but also can have psychosocial and cognitive effects from treatment. Utilizing secondary analysis, the purpose of this dissertation is to examine peripheral neuropathy (PN) trajectory during the second year of ALL treatment which has not been investigated in children receiving vincristine. Describing these symptom patterns in children carries the potential to guide future targeted nursing interventions. The Symptom Management Model will conceptually guide this three-manuscript dissertation to describe the patients' experience and the development of PN over year two of treatment.Chapter 2 (manuscript 1) examined the state of the science relative to valid and reliable assessment tools for measuring VIPN in pediatric patients receiving chemotherapy through a review of the literature. The results of the scoping review identified two valid and reliable measures (i.e., Ped-mTNS, mTNS©-PV), with one tool better suited for children (mTNS©-PV).Chapter 3 (manuscript 2) and Chapter 4 (manuscript 3) involve a secondary analysis using data collected from an observational, longitudinal, prospective, multi-center study, entitled The Advance Trial, funded by the National Cancer Institute. Chapter 3 (manuscript 2) characterizes the changes in VIPN in a retrospective sample of 77 children with ALL using the cumulative score of the modified TNS©-PV (1-20; higher = more severe) monthly at 12, 15, 18, 21, and 24 months and identifies which nerve pathway contributes to a higher VIPN cumulative score using the subscales of the modified TNS©-PV at the aforementioned time points. These results provide evidence that VIPN is persistent during the second year of ALL treatment and that the sensory/motor pathway is affected the most.Utilizing the same aforementioned data set, Chapter 4 (manuscript 3) examines whether the patient characteristics and treatment characteristics (i.e., race, sex, age, VIPN at 12 months) are associated with VIPN severity at 24 months based on the modified TNS©-PV cumulative score. The modified TNSÓ-PV scores were not correlated with age, sex, race or VIPN at 12 months. Female sex and VIPN at 12 months are associated with VIPN at 24 months as an interaction. Early identification of patients at risk for severe VIPN will enable nurses to proactively screen and monitor patients for peripheral neuropathy as well as recommend interventions to improve this population's functional status.Results from this three-manuscript dissertation add to the growing body of evidence showing a high incidence of PN in children, specifically sensory/motor neuropathy, that does not resolve during the second year of ALL treatment. Proactive assessment and early interventions directed toward children at risk to improve their physical function should be investigated. Studies in larger samples are needed to validate these findings. Patient and provider education is vital to prevent injuries and other complications of PN as well as to improve a patient's quality of life and physical functioning. Future research should focus on examining the psychosocial and cognitive disabilities resulting from PN, examining differences in symptom presentation and functioning between boys and girls with PN, and finding more effective means of treatment.

Child Neurology

Pathogenesis of Charcot - Marie - Tooth 1A ( CMT 1A ) neuropathy . ... Heterogeneity in X - linked recessive Charcot - Marie - Tooth neuropathy . ... Peripheral neuropathies in childhood : Gothenburg 1973–78 .

Author: John H. Menkes

Publisher: Lippincott Williams & Wilkins

ISBN: 0781751047

Category: Medical

Page: 1186

View: 568

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Revised to incorporate the latest advances in the neurosciences and clinical neurology, the Seventh Edition of this classic text provides practical, cost-effective problem-solving approaches to all diseases affecting the developing nervous system. In clinically relevant terms, the book explains how recent developments in molecular biology, genetics, neurochemistry, neurophysiology, neuropathology, and neuroimaging impact on diagnosis and treatment. Chapters focus on specific disorders or groups of disorders and emphasize differential diagnosis, disease course, treatment, and prognosis. This edition has a new chapter on mitochondrial cytopathies.

Pediatric Electromyography

This book describes how to perform nerve conduction studies and electromyography in children, and explains the relevant physiology and anatomy crucial to making a diagnosis.

Author: Hugh J. McMillan

Publisher: Springer

ISBN: 9783319613611

Category: Medical

Page: 407

View: 348

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This book describes how to perform nerve conduction studies and electromyography in children, and explains the relevant physiology and anatomy crucial to making a diagnosis. Relevant case presentations are included to aid learning, and the authors also focus on the practical applications of the test results, including discussions of major neuromuscular diseases amenable to diagnosis via electromyography. Pediatric Electromyography: Concepts and Clinical Applications is aimed at residents, technologists and staff pediatric neurologists, as a practical guide and exam study guide.

Childhood Acute Lymphoblastic Leukemia

Peripheral neuropathy is a dose limiting toxicity of vincristine. It can manifest with motor (e.g. weakness, gait disturbance), sensory (e.g. pain, numbness, tingling) or autonomic (constipation) symptoms.

Author: Ajay Vora

Publisher: Springer

ISBN: 9783319397085

Category: Medical

Page: 342

View: 744

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This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.