With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Human beings produce energy according to quantum principles. Therefore, human beings need to eat what is consistent with quantum biology. Human beings must eat quantum.This book will help you to eat in a way that is appropriate for the biology of our mitochondria-our source of life, our energy engines. The thousands of mitochondria in each of our cells are there only for us to produce energy. Altogether they number trillions, and we are dependent on them.- Even a strand of our hair cannot grow without the energy from mitochondria. - Our aging cells cannot be renewed without the energy produced by mitochondria.- We will not recover from diseases if mitochondria do not produce energy. We are dependent on that energy for something as simple as blinking an eye and something as vital as our immune system intercepting a cancer cell. All our life functions are dependent on that energy. We must secure that energy. And what's more, we must do this for every second of twenty-four hours a day. We must do whatever it takes for our mitochondria to produce that energy for us. We must give whatever source of energy they choose as fuel to these energy engines. Otherwise, we shall die. Our afflictions in illness and cures in treatment are the same for all of us: choosing the most appropriate fuel for our mitochondrial engine, so that it may produce the best energy. That is our fundamental task. That is our prime concern. The best fuel is the most appropriate one (nothing more) for our mitochondria's biology, our mitochondria's quantum biology. Classical biology is now inadequate in explaining the complex energy production in mitochondria. The new biology is quantum biology.If we want to stay alive for many years and live a healthy life, we cannot go against the unequivocal principles of biology. We receive energy that supplies our vitality according to quantum biological principles of mitochondria. In other words, we must abide by the rules of quantum biology. The medicine of the future will merely be to prevent initial damage. In the future, physicians will not be diagnosing diseases.Consequently, there will no longer be such a thing as curing diseases. Medicine, biophysics, biomedicine, quantum physics, and electronics will be intertwined, and the system faults will be dealt with at micro and molecular levels. There will be a greater need for quantum biologists than for surgeons.These are not exaggerations, they just need broader thinking. Since we accept that we are biological creatures, we must stop ignoring the biology of our smallest units-the cells, and the organelles inside them. The secret that makes the human being a special living species is hidden in the system inside these cells. The cells' own inner processes, energy production, intercellular communication, the cell systems' functioning as a whole, the cells being synchronized with the earth, sun, and universe occur entirely according to the rules of quantum biology. These are subatomic events that seem strange to us.Subatomic little particles (not just electrons and protons but quarks, tachyons, etc.) and information about their effects on health and vitality will in time be a source of amazement.Throughout this book, I have only attempted to clarify matters at the cell and mitochondria levels-the deepest points to which we can go down. If we can understand even this much, we can establish the link between our health and getting ill.

This guide examines the scientific world behind medical technologies and proves to be a thought-provoking introductory treatise on nanotechnology, stem cell technology, pharmacogenomics and other technologies.

Mitochondrial Intoxication: Dysfunction Induced by Toxicants explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria, and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. Mitochondrial Intoxication is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. Features a wide range of toxicants, and their effects on mitochondrial physiology Covers molecular markers of mitochondrial intoxication Includes case studies illustrating the health impacts of toxicity upon mitochondria Considers future directions regarding the study of mitochondrial intoxication

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

This book takes a whole new perspective concerning the approach to treating aging process. Most doctors feel they have no other options but to operate on the physical processes that occur as we grow older. Now, for the first time, there is another scientific approach that impacts on the causes of aging and not just on the effects. The basic principles and practice of anti-aging medicine and age management clearly and succinctly explains the solid scientific research behind doctor Giampapa's revolutionary theories, revealing that a key number of bio chemical processes at the cellular level can be clinically manipulated to successfully improve the physical signs of aging even without surgery. Dr. Giampapa gives the clinical dermatologist and plastic surgeon the knowledge and tools to successfully incorporate anti-aging medicine into their practice. These tools not only improve the longevity of their cosmetic procedures but markedly enhance the quality of life and health that patients can experience. Throughout the book a new concept of aging is built around preserving DNA function and replication. Treatment concepts are centered around: Controlling blood sugar levels and glycation; Inhibiting cellular inflammation; Supplying the correct combination of antioxidants; Improving gene regulation and methylation; Following a simple diet guide and exercise plan; Regulating age-related hormonal declines; Improving DNA repair and decreasing DNA damage. Containing hundreds of scientific medical references as a valuable resource for future investigation and information, this book is an essential addition to the cosmetic physicians library.

This book covers both the technological development and biomedical applications of NADH fluorescence. Topics covered include perspectives on the history of monitoring NADH fluorescence, the relationship between mitochondrial function and other functions at the tissue level, responses of NADH to physiological and pathophysiological conditions, monitoring of NADH in the human brain and other organs, and metabolism. It also includes an in-depth look at flavoprotein (Fp) fluorescence and NADH in relation to redox state. This is an ideal book for biomedical engineers, researchers, and graduate students interested in learning the biomedical applications of NADH fluorescence. This book also: Covers multisite monitoring of NADH, as well as multiparametric responses of NADH to physiological and pathophysiological conditions, and monitoring of various organs in various animal models Describes the relationship between brain activation (i.e. epileptic activity and cortical spreading depression) and NADH redox state Presents the effects of hypoxia,hyperbaric hyperoxia, and ischemia on brain NADH fluorescence and other tissue physiological parameters About the Author Avraham Mayevsky, Ph.D. is a Professor Emeritus in theFaculty of Life Sciences and the Brain Research Center at Bar Ilan University, Israel. He has published more than two hundred papers in the field of mitochondrial function and tissue physiology in vivo under pathophysiological conditions.

"Bestselling author David Agus unveils the brave new world of medicine, one in which we can take control of our health like never before and doctors can fine-tune strategies and weapons to prevent illness. In his first bestseller, The End of Illness, David Agus revealed how to add vibrant years to your life by knowing the real facts of health. In this book, he builds on that theme by showing why this is the luckiest time yet to be alive, giving you the keys to the new kingdom of wellness. Medicine is undergoing rapid change. In the old world, you followed general principles and doctors treated you based on broad, one-size-fits all solutions. In this new golden age, you'll be able to take full advantage of the latest scientific findings and leverage the power of technology to customize your care. Only those who know how to access and adapt to these breakthroughs--without being distracted by hyped ideas and bad medicine--will benefit. Imagine being able to get fit and lose weight without dieting, train your immune system to fight cancer, edit your DNA to avoid a certain fate, erase the risk of a heart attack, reverse aging, and know exactly which drugs to take to optimize health with zero side effects. That's the picture of the future that you can enter starting today. Welcome to The Lucky Years"--

Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.