Methods for Skin Absorption

This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies.

Author: Barbara W. Kemppainen

Publisher: CRC Press

ISBN: 0849346517

Category: Medical

Page: 244

View: 105

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This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.
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Methods for Skin Absorption

Choice of Membranes for In Vitro Uptake Studies and General Experimental Techniques; Penetrant Characteristics Influencing Skin Absorption; Instrumentation and Methodology for In Vitro Skin Diffusion Cells; Preparation of Biological ...

Author: Kemppainen BW Ed

Publisher:

ISBN: OCLC:985854309

Category:

Page:

View: 234

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Choice of Membranes for In Vitro Uptake Studies and General Experimental Techniques; Penetrant Characteristics Influencing Skin Absorption; Instrumentation and Methodology for In Vitro Skin Diffusion Cells; Preparation of Biological Membranes; Methodology for the Execution of In Vitro Skin Penetration Determinations; In Vivo Methods for Determining Percutaneous Absorption and Metabolism of Xenobiotics, Indirect Methods; Physical Resources Needed for In Vivo Animal Studies; Detection Methods; Data Interpretation and Analysis in Percutaneous Absorption Studies; Specialized Techniques, Congenitally Athymic (Nude) Animal Models; Specialized Technique, The Isolated Perfused Porcine Skin Flap (IPPSF); Validity of Skin Absorption and Metabolism Studies.
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Percutaneous Absorption

Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous ...

Author: Nina Dragićević

Publisher: CRC Press

ISBN: 9780429511561

Category: Medical

Page: 1008

View: 746

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Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
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OECD Guidelines for the Testing of Chemicals Section 4 Health Effects Test No 428 Skin Absorption In Vitro Method

This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a ...

Author: OECD

Publisher: OECD Publishing

ISBN: 9789264071087

Category:

Page: 9

View: 479

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This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
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Predictive Methods in Percutaneous Absorption

J Pharm Sci 80:744–749 Fedors RF (1974) A method for estimating both the solubility parameters and molar volumes of liquids. Polymer Eng Sci 14:147–154 Fiserova-Bergerova V, Pierce JT, Droz PO (1990) Dermal absorption potential of ...

Author: Gary P. Moss

Publisher: Springer

ISBN: 9783662473719

Category: Medical

Page: 199

View: 650

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This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
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Predictive Methods in Percutaneous Absorption

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation.

Author: Gary P. Moss

Publisher: Springer

ISBN: 3662508311

Category: Medical

Page: 0

View: 382

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This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
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Drug Absorption Studies

Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicol. Appl. Pharmacol. 62:481–488 (1982). H. R. Moghimi, B. W. Barry, and A. C. Williams. Stratum corneum and barrier performance: A model ...

Author: Carsten Ehrhardt

Publisher: Springer Science & Business Media

ISBN: 9780387749013

Category: Medical

Page: 696

View: 185

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This is a well thought-out, highly practical text covering contemporary ‘in vitro’ techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.
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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Drug Manipulation Strategies and Vehicle Effects Nina Dragicevic, Howard I. Maibach ... The highest absorption (drug storage in the skin) was observed for the aqueous, enhancer-free solution and the gel containing the penetration ...

Author: Nina Dragicevic

Publisher: Springer

ISBN: 9783662450130

Category: Medical

Page: 341

View: 402

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This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. The fourth volume discusses the diverse physical methods used in penetration enhancement, such as sonophoresis, iontophoresis, electroporation, microporation, laser ablation, and microneedles. Determination of drug penetration is covered in the final volume, with a focus especially on mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. This edition of Percutaneous Penetration Enhancers will be an invaluable resource for researchers, pharmaceutical scientists, practitioners, and also students.
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Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds

This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics.

Author: Kenji Sugibayashi

Publisher: Springer

ISBN: 9784431565260

Category: Medical

Page: 428

View: 122

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This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.
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Models for Assessing Drug Absorption and Metabolism

Table IV Percutaneous Absorption and Metabolism of Retinyl Palmitate Skina Receptor fluid" Radioactivity absorbed ... COMPARISON OF MODEL TO OTHER METHODS Only in vitro diffusion cell techniques can reliably measure skin metabolism as ...

Author: Ronald T. Borchardt

Publisher: Springer Science & Business Media

ISBN: 9781489918635

Category: Medical

Page: 444

View: 616

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Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.
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