Nuclear Analytical Techniques for Metallomics and Metalloproteomics

Metallomics. in. Metal-based. Drugs. RUIGUANG GE,a, b IVAN K. CHUa AND HONGZHE SUNa,* aDepartment of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Hong Kong, P. R., China; bThe Laboratory of Integrative ...

Author: Chunying Chen

Publisher: Royal Society of Chemistry

ISBN: 9781847559012

Category: Science

Page: 428

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The intent of this book is to provide readers with a comprehensive view of application of advanced nuclear analytical techniques for metallomics and metalloproteomics, both areas emerging as scientific hot topics in bioanalytical and inorganic chemistry and biochemistry. Metallomics and metalloproteomics study is not only for chemists involved in nuclear techniques and speciation, it also be important for environmental, nutritional and clinical researcher and drug developer. This authoritative book sets out to emphasize and describe the superiority of nuclear analytical techniques and the importance of metallomics and metalloproteomics study in the multidisciplinary research field. Analytical chemists and scientists working on bioanalytical and inorganic chemistry and biochemistry of metals; or on metabolic or environmental related speciation studies will find this book an invaluable reference point.

Metallomics

Metallomics 2(2):103 Sperling M (2011) The third international symposium on metallomics 2011. Metallomics 3 (12):1263–1264 Montes-Bayon M, Bettmer J (2014) 4th international symposium on metallomics, 2013. Metallomics 6(2):187–188 ...

Author: Yasumitsu Ogra

Publisher: Springer

ISBN: 9784431564638

Category: Medical

Page: 364

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This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.

Metallomics

Metallomics is an emerging area of the omics-science that is growing since its recent conception. This area integrates the researches related to biometals, in symbiosis with genomics, proteomics, and metabolomics.

Author: Marco Aurélio Zezzi Arruda

Publisher: Springer

ISBN: 9783319901435

Category: Science

Page: 279

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This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.

Metallomics

1.4 Approaching the Metallome: Study of Metallome Subgroups The previous section described the dilemma between the claim of metallomics as the global study of the metallome and the reality given by the limitations of available ...

Author: Bernhard Michalke

Publisher: John Wiley & Sons

ISBN: 9783527339693

Category: Science

Page: 498

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Latest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health.

Metallomics

without specifying its significance and contribution to a system should not be referred to as metallomics”. Hiroki Haraguchi also pointed out that in addition to the metallomes in the biosphere different metallomes can be investigated ...

Author: Wolfgang Maret

Publisher: World Scientific Publishing Company

ISBN: 9781783268306

Category: Science

Page: 156

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Metallomics is an integrated biometal science as it unifies different disciplines into a mainstream subject that can be taught to students of the biological and biomedical sciences. Metallomics bridges chemistry and the biological sciences from a global and quantitative systems approach, while the biological context provides new insights into the functions of metals in biological cells. The book challenges the traditional view of relating biochemistry only to organic chemistry, and discusses the structure and function of metal ions in the context of their environment in organisms. This is an essential read for undergraduate and graduate students in the fields of biochemistry, cell biology, nutrition (trace element research), toxicology, pharmacology and ecology.

Metallomics and the Cell

R. A. Colvin, W. R. Holmes, C. P. Fontaine, W. Maret, Metallomics 2001, 2, 306—317. H. Haase, W. Maret, in Cellular and Molecular Biology afMetals, Eds R. Zalups, J. Koropatnick, Taylor & Francis, Boca Raton, 2010, pp. 179—210.

Author: Lucia Banci

Publisher: Springer Science & Business Media

ISBN: 9789400755611

Category: Science

Page: 609

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Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Plant Metallomics and Functional Omics

In line with the development of “omic” technologies, such as genomics and proteomics, metallomics emerged as a field attracting more and more attention. The concepts and terms “metallomics” and “metallomes” for “integrated bio-trace ...

Author: Gaurav Sablok

Publisher: Springer

ISBN: 9783030191030

Category: Science

Page: 332

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Major portion of the planet earth is covered by seas and oceans representing 96.5% of the planet’s water, playing a detrimental role in sustaining the plant including crop diversity and productivity for human consumption. Water resources contain both soluble and transition metals, which are easily absorbed by plants through roots as a first point of contact and subsequently play important physiological and biological functions in plants. Transition metals such as copper (Cu), iron (Fe), manganese (Mn) and zinc (Zn) contribute to the plant productivity by playing key functional roles in the photosynthesis. In addition, to their major role in regulating the plant productivity, they also play an important role by acting as homeostatic regulators in uni-parentally inherited chloroplasts and maintains the flow of the electron transfer. It is worthwhile to mention that they play a critical role as transporters, which acts as electron balancing units for managing the electrostatic potential across the membranes. In contrast, some metals such as Cd, As play a significant role in inducing the stress mechanism and influencing either directly or in-directly Haber-Weiss reactions either through the production of the reactive oxygen species (ROS) or through the membrane damage thus leading to leakage of membrane transporters. However, besides playing a detrimental role as transporters in plant system, excessive accumulation of these metals due to the increasing contamination in the marginal soil and water are posing important threats to the plant system. Realizing the toxic effects of the metals, several physiological evidences have been laid for the credence of the metal toxicity and their concurrent effect on plant productivity. Increasing effects of the metals as toxicants can have three adverse effects on the populations: population can move, persist via local adaptation or phenotypic plasticity, or die. Next generation sequencing studies have revolutionized our abilities to detect the changes in expression profiles across an array of genes, which can in-turn help to develop early markers of metal induced stress. Plant Metallomics and Functional Omics: A System-Wide Perspective focuses on the applications of the system wide understanding of the biological and functional interplay occurring at the juncture of the metalloid induced stress and toxicity. The main goal of this book is to familiarize the readers with the most up-to-date information on metal-induced physiological changes in plant species.

Proceedings

iii ) quantitative information is relatively easy to obtain . speciation analysis is really important in metallomics In addition , the informations about the metals available research . The security and quality of food is an important ...

Author: National Academy of Sciences, India

Publisher:

ISBN: CHI:80465794

Category: Science

Page:

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Journal de physique

[ 131 ] , with permission ) . metallomics concept has been introduced as an analogy to proteomics , defined as the study of the proteome of an organism ( the entire protein complement of a given genome , that is , the entirety of the ...

Author:

Publisher:

ISBN: CHI:77361585

Category: Physics

Page:

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