Liver Cells and Drugs

Liver Cells and Drugs . Ed . A. Guillouzo . Colloque INSERM / John Libbey Eurotext Ltd. O 1988. Vol . 164 , pp . 3-12 . Drug - induced hepatitis : clinical aspects Jean - Pierre Benhamou INSERM U. 24 , Hôpital Beaujon , 92118 Clichy ...

Author: André Guillouzo

Publisher: John Libbey Eurotext

ISBN: 0861961285

Category: Drugs

Page: 520

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This book contains the 17 lectures given at the International Symposium on Liver Cells and Drugs held in Rennes on 7 to 10 July 1987 as well as 50 communications presented at the poster sessions.

Drugs and the Liver

It aims to: enable the practitioner to assess liver function using biochemical markers, other tests, signs, symptoms and disease knowledge; identify which pharmacokinetic and pharmacodynamic parameters of a drug are likely to be affected by ...

Author: Penny North-Lewis

Publisher:

ISBN: UOM:39015073936794

Category: Medical

Page: 324

View: 181

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Liver disease is a widespread and increasing problem throughout the world, however little is published on how different types and degrees of liver dysfunction affect the body's ability to handle medicines."Drugs and the Liver" is designed to assist practitioners in making pragmatic choices for their patients. It aims to: enable the practitioner to assess liver function using biochemical markers, other tests, signs, symptoms and disease knowledge; identify which pharmacokinetic and pharmacodynamic parameters of a drug are likely to be affected by different types of liver disease; and consider the impact of a drug's side effects on a patient with liver disease.This practical guide covers background information on liver function, the principles of drug use in liver disease and includes a section of worked examples of commonly asked questions. It will be invaluable to clinical pharmacists and anyone making medicine choices in patients with liver impairment.

Drug Hepatotoxicity An Issue of Clinics in Liver Disease E Book

Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease.

Author: Vinod Rustgi

Publisher: Elsevier Health Sciences

ISBN: 9780323496629

Category: Medical

Page: 276

View: 961

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Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease. Articles are devoted to: Drug metabolism in the liver; Mechanism of Liver Damage including the RUCAM scale; Drug-induced acute liver failure; Epidemiology and genetic risk factors; Adverse drug reactions: type A (intrinsic or pharmacological) or type B (idiosyncratic); Pathology of injury including phenotypes; The clinical course of drug-induced liver disease; Environmental factors of drug hepatotoxicity; Newer agents in drug hepatotoxicity; Drug hepatotoxicity: herbal products; Drug hepatotoxicity: models including “human on a chip and zebrafish; Acute and chronic liver failure from drugs: impact on the kidney; and Management of acute hepatotoxicity including medical agents and liver support systems. Readers will come away with the cutting edge science behind the latest innovations in the treatment of Hepatitis B.

Liver Cirrhosis and Its Development

This book, therefore, will interest clinically oriented basic scientists as well as those in clinical practice, givng an update on many aspects of modern hepatology and its perspectives in the next millennium.

Author: J.L. Boyer

Publisher: Springer Science & Business Media

ISBN: 0792387600

Category: Medical

Page: 374

View: 227

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Liver cirrhosis is a major clinical problem worldwide and is associated with significant morbidity and mortality from its complications, such as liver cell insufficiency with coagulopathy and hepatic encephalopathy, portal hypertension with ascites and gastrointestinal bleeding, hepatorenal syndrome, HCC development and others. This volume, the proceedings of Falk Symposium 115 held in Basel, Switzerland, October 22-24, 1999 (Part II of the Basel Liver Week 1999; XI International Congress of Liver Diseases) covers our present knowledge of the aetiologies and early stages of liver cirrhosis development. Based on this information, strategies are discussed that are aimed at the prevention, early diagnosis and therapy of chronic liver diseases, thus preventing their progression to cirrhosis and its complications, including HCC development. The main topics mentioned above are complemented by three state-of-the-art chapters on modern aspects of medicine in general and hepatology in particular as well as their perspectives beyond the year 2000: `Molecular Medicine', `New Hepatitis Viruses' and `Genetic Liver Diseases: Diagnosis and Therapy'. Introductory chapters focusing on the more basic aspects of the biology of live cells as well as on the mechanisms underlying fibrogenesis, cholestasis and inflammation will be followed by a detailed discussion of the clinically most important causes of liver cirrhosis worldwide: hepatitis viruses B, C and D; toxins (alcohol, drugs and others) as well as metabolic liver diseases (haemochromatosis, Wilson disease, alpha-1-antitrypsin deficiency, porphyria cutanea tarda and protoporphyria). This book, therefore, will interest clinically oriented basic scientists as well as those in clinical practice, givng an update on many aspects of modern hepatology and its perspectives in the next millennium.

Drug Metabolism Liver Injury and Ageing

proceedings of the EURAGE Meeting of the Liver and Drugs Section, Cardiff, Wales, November 21-23, 1991 EURAGE. ... Rojkind and E. Wisse Connective tissue gene transcripts in fat-storing cells of CCL4 intoxicated rat liver A.W. Burr, SJ.

Author: EURAGE. Liver and Drugs Section. Meeting

Publisher:

ISBN: UCLA:L0067137760

Category: Aging

Page: 280

View: 320

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Mechanisms of Drug Toxicity

due to an increased turnover of liver cells. Chronic treatment with halothane produces during the first 4 weeks hypertrophy similar to that induced by barbiturates. In a later stage, after 2 and 6 months treatment, there is in addition ...

Author: H. Rašková

Publisher: Elsevier

ISBN: 9781483157207

Category: Medical

Page: 114

View: 381

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Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

Antimalarial Drugs I

In addition to hyperplasia and hyperactive phagocytosis by Kupffer cells, the liver cells showed mild to severe degeneration with necrosis of individual cells. Mitosis of liver cells was prominent. Acute and chronic inflammatory cell ...

Author: Wallace Peters

Publisher: Springer

ISBN: 9783662353264

Category: Medical

Page: 486

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WHAT ELITE ATHLETES EAT

When the liver enzymes become significantly elevated doctors either lower the dose of statin drugs or stop the drugs. In order for statins to work enough liver cells must ultimately be slowed in their production of cholesterol ...

Author: Deborah M. Westphal, RPh, BCNSP (Registered Pharmacist, Board Certified Nutrition Support Pharmacist)

Publisher: CeeJayEnterprizes

ISBN:

Category: Health & Fitness

Page: 1964

View: 877

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Talking to Elite Athletes and to Americans we noticed Americans do not have knowledge of what their own NBA stars, Olympic teams, and Pro Football teams eat to be elite athletes. Most of us would delight to eat what these stars eat. If only we knew. What Elite Athletes Eat is Scepter Nutrition. The program is completely different from the average American diet. We should all be so lucky to eat the same delicious food. Don’t worry that these athletes are more active than us; the average American burns as many calories on thinking, studying, or stress as the elite athlete burns in training. Athletes are not into hunger, deprivation programs, or feeling weak. They demand performance from their nutrition programs. Jenny Thompson (12 Olympic Medals – 8 Gold), James Donaldson, NBA Star, and Pablo Morales (2 Olympic Gold Medals) are some of the athletes that first bought into nutrition rich in fats with controlled servings of protein and carbs. By doing this they not only rose to the top of their sport, they extended their athletic careers far beyond others in their sports. Elite athletes have further refined these principles, resulting in the Scepter Nutrition Plan. WHAT ELITE ATHLETES EAT also known as Scepter Nutrition flies in the face of what most of us have heard from our sports coaches, doctors AMA (American Medical Association), public schools, MY PLATE, School Lunch Program, the US Surgeon General, the USDA (United States Department of Agriculture, ADA (American Diabetes Association) and the popular published fad diets. WHAT ELITE ATHLETES EAT in their Scepter Nutrition Plan is the exact opposite of these programs. Some things are immutable, they do not mutate, they do not change, and they are truth. The human body was created to be optimally sustained by a certain fuel mix (nutrient mix). This fuel mix will not change and has not changed for centuries. No amount of fad diets, advertising, government MY PLATE programs, or USDA Food Pyramid recommendations is going to change the way our bodies are designed to operate. Two of those immutable truths are: first that the human body is designed to use select fat, protein and carbohydrate in a ratio of 60%-17%-23% (in calories) and secondly the body is also designed to operate best within tightly controlled carb and protein servings based on your body size which can be easily determined visually based on the size of your hands to achieve peak performance. Experience with elite athletes over the past 20 years has demonstrated that they perform best when they apply these principles. This has also been demonstrated in select nutrition research trials over the same 20 years, where we precisely control everything given to patients. When an athlete wants to be best at a sport, they go find the best mentors and coaches they can. They find someone who can beat them and compete and train with them. They don’t find someone they can already beat and ask them to train them. Athletes are turning to other elite athletes to train them in nutrition as well as their sport. Athletes are ahead of us and we can learn from them and enjoy their same delicious food. Elite Athletes are breaking world records more and more frequently. Much of the credit goes to nutrition breakthroughs that have been documented to dramatically improve performance of the finest athletes trained by the world’s best coaches at their documented peak performance levels to move beyond what even they and their coaches thought possible.

Hypersensitivity to Drugs

Popper, H., Rubin, E., Gardiol, D., Schaffner, F., and Paronetto, F. C. (1965) Drug-induced liver disease. ... Rees, K. R. (1964) Mechanism of Action of Certain Exogenous Toxic Agents in Liver Cells in Cellular Injury (A. V. S. DeReuck, ...

Author: Lennart Angervall

Publisher: Pergamon

ISBN: UOM:39015072262374

Category: Drug allergy

Page: 439

View: 957

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