Leukaemia Diagnosis

From the bestselling author, Barbara J. Bain, the new edition of this practical reference on the principles of leukaemia diagnosis and classification has been fully updated, and incorporates the recently revised WHO classification.

Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 9781119210504

Category: Medical

Page: 576

View: 683

DOWNLOAD →

UP-TO-DATE PRACTICAL GUIDE TO LEUKAEMIA DIAGNOSIS Written by a renowned expert this practical guide had been fully revised and updated. The book covers recent advances in the fields of immunophenotyping, cytogenetics and molecular genetics. It illustrates how laboratory techniques are used for the diagnosis and classification of leukaemia and includes images of abnormal cells to aid diagnosis. This fifth edition: Incorporates the recommendations of the 2015 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Includes 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma Full colour diagrams and helpful tables clarify and summarise key points throughout Essential reading for every haematologist and haematopathologist.

Leukaemia Diagnosis

This volume will be a comprehensive visual guide to the most important of the classifications to have evolved - the French-American_British (FAB) cooperative group classification.

Author: Barbara J. Bain

Publisher: Lippincott Williams & Wilkins

ISBN: UOM:39015018828338

Category: Medical

Page: 116

View: 714

DOWNLOAD →

Leukaemia is a complex group of diseases characterized by abnormal changes in any or several of the types of white blood cells. Because of the complexity of the various leukaemias, a systematic classification is essential to all involved in the study, analysis and assessment of the condition. This volume will be a comprehensive visual guide to the most important of the classifications to have evolved - the French-American_British (FAB) cooperative group classification. This system is used in Haematology departments throughout the world. But despite this widespread use, details of the system have yet to be contained in a single volume.

Leukaemia Cytochemistry and Diagnosis

features beforehand, the concordance rate for subclassification of acute leukaemias into AML and ALL was only in the range of 70-90% (Fig. 1.1) [2, 4]. Agreement was so ioo o Fig. 1.1 — Studies on the reproducibility of morphological-cy ...

Author: Colin Stephen Scott

Publisher:

ISBN: UOM:39015018472228

Category: Acute leukemia

Page: 387

View: 226

DOWNLOAD →

Leukemia

In this volume, thirteen in-depth reviews from large multicenter trials in the Federal Republic of Germany summarize the current state of diagnosis and management of leukemias. Childhood ALL and AML adult ALL and AUL were investigated.

Author: E. Thiel

Publisher: Springer Science & Business Media

ISBN: 9783642822490

Category: Medical

Page: 308

View: 895

DOWNLOAD →

Much of the attention presently paid to leukemia is the result of recent progress in understanding and treatment. Chemotherapy of leukemia started in the late 1940s, and combination therapy evolved in the late 1950s. It was at that time that the clonality of leukemia was realized, after the discovery of chromosomal and then biochemical and immunological markers. And now we have the new data on retroviral and cellular oncogenes and the reports on human T -cell lymphoma/ leukemia viruses. Many more steps forward could be enumerated in a field which is so rapidly making the hematological textbooks outdated. In this volume, thirteen in-depth reviews from large multicenter trials in the Federal Republic of Germany summarize the current state of diagnosis and management of leukemias. Childhood ALL and AML adult ALL and AUL were investigated. While cure appears to be achievable for more and more patients with acute leukemia, we still pursue the aim of optimal palliation in chronic leukemias. The management of patients with leukemia therefore varies to a large extent in aggressiveness of therapy. In some situations, rescue from an otherwise lethal disease is provided by bone marrow transplanta tion, which is discussed in two chapters.

Leukaemia Diagnosis

... immunophenotyping, 526 regions (chromosomal), 108 relapses, B lymphoblastic leukaemia/ lymphoma, 253 remission criteria, 13 rates, t(8;21)(q22;q22.1) AML, 143 resource‐poor countries, leukaemia diagnosis, 525–537 reticulocytes, ...

Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 9781119210542

Category: Medical

Page: 576

View: 803

DOWNLOAD →

The nature of leukaemia, cytology, cytochemistry and the morphological classification -- Immunophenotyping and cytogenetic/molecular genetic analysis -- Acute myeloid leukaemia, integration of morphological, immunophenotypic and genetic information and the WHO classification -- Acute lymphoblastic leukaemia and acute leukaemia of ambiguous lineage -- The myelodysplastic syndromes and the myelodysplastic/myeloproliferative neoplasms -- Chronic myeloid leukaemias -- Lymphoid leukaemias of mature T, B, and natural killer cells -- Leukaemia diagnosis in resource-poor countries

Acute Leukemia

This book addresses all aspects of AML and ALL including their risk factors, cytogenetics and mutational characteristics, diagnoses, clinical management and prognoses which are imperative and challenging for medical students, residents, ...

Author: Ashkan Emadi, MD, PhD

Publisher: Springer Publishing Company

ISBN: 9781617052774

Category: Medical

Page: 376

View: 131

DOWNLOAD →

Acute Leukemia: An Illustrated Guide to Diagnosis and Treatment provides a comprehensive and concise visual reference on acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) seen in children and adults. This book addresses all aspects of AML and ALL including their risk factors, cytogenetics and mutational characteristics, diagnoses, clinical management and prognoses which are imperative and challenging for medical students, residents, hematology and medical oncology fellows, and even community oncologists and hematologists. It presents complex information relying predominantly on pictorial depictions rather than traditional text in a visually instructive format. It replaces the wordiness of a traditional textbook with original and adapted illustrations, instructive schemata and diagrams, photomicrographs, tables, detailed figure legends, and practical, ‘bite-sized’ text. The result is a visually engaging book that is easy to read, review, and remember. Crafted by world experts in the field, this digestible volume provides you with the must-know information that you can utilize when encountering AML and ALL patients who require immediate attention. Whether you are an early-career practitioner looking for quick guidance to managing a deadly disease or you are a seasoned clinician looking for a quick review of treatment protocols, this engaging format provides a unique and ‘go-to’ resource. Key Features: Contains over 40 tables and over 220 illustrations, histologic photomicrographs, flow diagrams, graphs, and schemata with detailed figure legends Presents complex scientific aspects such as cytogenetics and molecular mutations in a visually digestible and easy-to-understand format Provides helpful and evidence-based treatment recommendations when providing induction therapy, consolidation therapy, and bone marrow transplantation Includes unique chapters on managing psychosexual issues accompanying AML and ALL treatment as well as on the FDA drug development and clinical trial design process Includes digital access to the e-book as well as an online Image Bank

Acute Myeloid Leukaemia

In this collection, the authors explore risk factors for acute myeloid leukemia, newer epidemiologic studies on the connections between these risks and clinical phenotypes and outcomes of the disease.

Author: Irvin Mendez

Publisher:

ISBN: 1536143456

Category:

Page: 111

View: 870

DOWNLOAD →

Acute myeloid leukemia is the most common adult acute leukemia, but its etiology in individual patients is poorly understood. An increased risk of acute myeloid leukemia may be inherited (through congenital hematologic diseases and syndromes or germline disorders) or be acquired due to a lifetime of exposure to environmental or chemical agents, or genotoxic stress. In this collection, the authors explore risk factors for acute myeloid leukemia, newer epidemiologic studies on the connections between these risks and clinical phenotypes and outcomes of the disease. The subsequent chapter evaluates different prognostic factors and stratifications of risk that have been published in the attempt to assess the influence of acute myeloid leukemia progression on the overall survival of myelodysplastic syndromes patients, evaluating them in a population-based registry. Many acute myeloid leukemia patients cannot tolerate standard chemotherapy due to its high toxicity. A milder therapy for acute myeloid leukemia has long been sought after, and until now the only successful clinical application has been all-trans-retinoic acid-based therapy for just one subtype of acute myeloid leukemia, acute promyelocytic leukaemia. The concluding chapter aims to address other therapeutic candidates.

One Carer s Account of Living with Her Husband s Leukaemia Diagnosis

But this book is also a testament to the unfailing love and care of his wife, Jennifer, whose selfless devotion shines through her account - not only of coping with Peter's illness, but poignant memories of their life together, family ...

Author: Jennifer Rogers

Publisher: Austin MacAuley

ISBN: 1786933780

Category: Leukemia

Page: 226

View: 413

DOWNLOAD →

In 2011, Peter Rogers was diagnosed with a rare form of leukaemia. For a fit and active man, recently retired, the news was devastating. Written by his wife, Jennifer, this is the story of Peter's battle with the disease, expressing the highs and crushing lows of the last three years of his life. Through chemotherapy, blood transfusions and bone marrow transplants, Peter kept meticulous notes: recording both the details of his treatment and his appreciation of the care he received from doctors and other dedicated healthcare staff. But this book is also a testament to the unfailing love and care of his wife, Jennifer, whose selfless devotion shines through her account - not only of coping with Peter's illness, but poignant memories of their life together, family gatherings and happy holidays with friends. Many will relate to this heart-rending but all-too-common account of love and loss.

Bone Marrow Diagnosis

Practical and highly illustrated this edition has been comprehensively updated whilst remaining succinct and concentrating on the core information necessary to make an accurate diagnosis.

Author: Kevin Gatter

Publisher: John Wiley & Sons

ISBN: 9781118952054

Category: Medical

Page: 232

View: 178

DOWNLOAD →

Bone Marrow Diagnosis is an essential resource for all those who need to report bone marrow trephine biopsies. The text will be succinct and concentrates on the core information necessary to make an accurate diagnosis. Each diagnostic entity will be accompanied by high quality images which show typical and more unusual examples of histological features. Each section will be comprehensively revised by an international team of authors. Over 900 high quality colour images will accompany each diagnostic entity. There will be coverage of cytology in sections relating to myeloid dysplasias and acute leukaemias, as well as incorporating new WHO classification of lymphomas and leukaemias. The digitally photographed and remastered images in this new edition will be of the highest quality, put onto disk directly from the microscope in digital format and reproduced in print form. The text will give comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. It will cover the disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Chapters close with a summary of key points. The consistent approach to describing each condition makes this a valuable reference tool for the trainee and practicing histopathologists, pathologists and haematologists.

Immunological Diagnosis of Leukemias and Lymphomas

Consequently the number of leukemias which are unclassifiable by immunological methods have dwindled down to a small mi nority. New facts give rise to new questions.

Author: S. Thierfelder

Publisher: Springer

ISBN: 3540082166

Category: Medical

Page: 390

View: 918

DOWNLOAD →

This two-and-a-half-day symposium has concentrated on main aspects of the rapidly expanding field ofleukocyte markers in hematology. While leukemias are already being 'phenotyped' routinely in clinical centers, continued research on the developmental sta ge of cells and cell membranes, expanding into a malignant clone, permits new snap shots on hemopoietic differentiation. Thus the discovery of leukemia-associated anti gens, which so far have not been found on subpopulations of normal cells, has greatly stimulated the discussion on 'differentiation antigens versus tumor antigens'. The proceedings reflect the considerable success which has been achieved very re cently in the classification of hemoblastomas. Consequently the number of leukemias which are unclassifiable by immunological methods have dwindled down to a small mi nority. New facts give rise to new questions. By including the main points of the discussions in the proceedings, we wanted to give the reader an opportunity to get an impression of the questions and conclusions raised and drawn by the participants on the basis of new - and frequently still unpublished - data. The editors thank both the contributors to this symposium, who made it a successful meeting and submitted their manuscripts punctually, and the publishers, who have provided a volume of high quality in good time. They are also grateful for the valuable cooperation from numerous colleages at the Institut fUr Hamatologie.

Chronic Lymphocytic Leukemia

This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research.

Author: Michael Hallek

Publisher: Springer

ISBN: 9783030113926

Category: Medical

Page: 179

View: 490

DOWNLOAD →

This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.

Chronic Lymphocytic Leukemia

This book reviews the diagnosis, treatment options and prognosis of CLL.

Author: Kimberly Rodriquez

Publisher:

ISBN: 1634855108

Category:

Page: 133

View: 306

DOWNLOAD →

Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the western world, seen mostly in the elderly age-group and has a very variable clinical outcome. Traditionally considered an indolent, antigen inexperienced leukemia of slowly accumulating cells that do not die, researchers now acknowledge that CLL cells are highly proliferative, antigen experienced cells that have a high cell turnover and a subset show an aggressive clinical course. The onset of the disease is usually asymptomatic; only abnormalities in whole blood count such as leukocytosis with lymphocytosis are found. Nowadays, CLL is diagnosed more often at an early, asymptomatic stage due to more frequent routine blood tests. More advanced stages are characterized by lymphadenopathy, hepatomegaly/splenomegaly, recurrent infections, weakness, pallor and hemorrhagic diathesis, and general symptoms such as weight loss, fever and night sweats are observed. This book reviews the diagnosis, treatment options and prognosis of CLL.

Diagnosis of Acute Myeloid Leukaemia

This book comprises a series of chapters from experts in the field of diagnosis and treatment of myeloid leukemias from all over the world, including America, Europe, Africa and Asia.

Author: Anca Bacârea

Publisher:

ISBN: 9533078863

Category:

Page:

View: 556

DOWNLOAD →