Cholesterol Lowering Therapies and Drugs

Covering recent progresses in cholesterol-lowering drugs and therapy, this book describes the natural and pharmaceutical products that are in clinical uses to lower cholesterol and lipids and compares these drugs in responses to different ...

Author: Chunfa Huang

Publisher: BoD – Books on Demand

ISBN: 9789535127345

Category: Medical

Page: 188

View: 622

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Using natural products and developing pharmaceutical drugs are emerging topics to reduce blood cholesterol levels for preventing heart disease and stroke. Covering recent progresses in cholesterol-lowering drugs and therapy, this book describes the natural and pharmaceutical products that are in clinical uses to lower cholesterol and lipids and compares these drugs in responses to different diseases such as homozygous familial hypercholesterolemia, atherosclerosis, cardiovascular disease, and cancer. The relationship between ethnicity and cholesterol-lowering drug responses is also reviewed. Each chapter is a building block for the book, but each individual chapter is also a complete subject package for the readers. Researchers from basic and clinic science interested in lipid and cholesterol metabolism, regulation, and lowering will find this book very useful. Features: - Up-to-date information of the molecular mechanisms of cholesterol lowering, the drugs from natural and pharmaceutical products, and their associated therapeutic strategies in human diseases. - Discussion of the pathogenesis of several human diseases, which are associated with high cholesterol levels and evaluation of the results of different cholesterol-lowering drug treatment in these diseases. - Discussion of the combinations of cancer chemotherapy and cholesterol lowering in potential cancer treatment and cancer prevention by cholesterol-lowering drugs. - Critical analysis of the effect of ethnicity on responses to cholesterol-lowering drug therapy leading to rational dose adjustment of cholesterol-lowering drugs for different people use.

The Truth About Statins

Discusses the uses, misuses, dangers, and benefits of statin drugs, counseling patients on how to make informed choices about side effects and lifestyle changes that can promote cardiovascular health.

Author: Barbara H. Roberts

Publisher: Simon and Schuster

ISBN: 9781451656398

Category: Health & Fitness

Page: 308

View: 994

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Discusses the uses, misuses, dangers, and benefits of statin drugs, counseling patients on how to make informed choices about side effects and lifestyle changes that can promote cardiovascular health.

Lipid Lowering Therapy and Progression of Coronary Atherosclerosis

Metabolic variables found to be significantly correlated with progression of coronary artery disease in angiographic trials of lipid-lowering therapy”. See text for discussion. Positive correlates Negative correlates • Total cholesterol ...

Author: A.V. Bruschke

Publisher: Springer Science & Business Media

ISBN: 9789400901438

Category: Medical

Page: 240

View: 115

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A unique overview of all major angiographic lipid intervention trials, presented by their principal investigators. Basic mechanisms and methodological aspects, including biochemical as well as angiographic aspects, are discussed by experts in these fields. A careful comparison of all available data permits an analysis to be made of what may currently be considered proved, which aspects merit further investigation, and which hypotheses should be rejected. Audience: Clinicians involved in the practice of lipid lowering and investigators involved in lipid-lowering clinical trials. Scientists involved in other areas of lipid research and investigators conducting coronary angiographic trials designed to study the influence of different interventions will find a wealth of information and practical guidelines in this book.

Cholesterol Lowering Therapy

This timely reference reviews the vast body of clinical trial evidence supporting the once controversial view that high levels of serum cholesterol are a major risk factor in coronary heart disease (CHD).

Author: Scott M. Grundy

Publisher: CRC Press

ISBN: 082478216X

Category: Medical

Page: 352

View: 797

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Reveals important new results from clinical trials conducted in Scandinavia, Scotland, Australia, Canada, and the United States. This timely reference reviews the vast body of clinical trial evidence supporting the once controversial view that high levels of serum cholesterol are a major risk factor in coronary heart disease (CHD). The studies presented in Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence promote cholesterol reduction as a highly successful means of preventing heart disease in various populations. Investigates past, current, and upcoming controlled clinical trials of cholesterol-reduction therapies, comparing effects of statins and bile acid sequestrants to triglyceride-lowering drugs and antioxidants. Written by more than 25 distinguished international researchers, Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence highlights historical studies of dietary trials designed to reduce CHD covers tests of HMG CoA reductase inhibitors for patients with and without CHD illuminates CHD risk factors such as diabetes, hypertension, obesity, and smoking explores blood levels of homocysteine and lipoprotein(a) and other recently identified CHD risk factors reviews metabolism of lipoproteins expressed in high (HDL) and low (LDL) density lipoprotein cholesterol and more! Containing over 700 instructive tables, drawings, photographs, and bibliographic citations, Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence is a must-read resource for cardiologists, pharmacologists, and upper-level undergraduate, graduate, and medical school students in these disciplines.

New Lipid Lowering Therapies for Cardiovascular and Metabolic Diseases Lessons from the Past and Future Challenges

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The scandinavian ... 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report ...

Author: Ahmed Bakillah

Publisher: MDPI

ISBN: 9783039216765

Category: Science

Page: 116

View: 801

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This book illustrates some of the most recent research efforts that have been made in lowering plasma cholesterol levels in patients with CVD. Selected articles aimed to illuminate advances and urgent challenges in the management of CVD, including disease management using statin-combined therapeutic strategies.

Cholesterol Lowering Therapies and Drugs

Covering recent progresses in cholesterol-lowering drugs and therapy, this book describes the natural and pharmaceutical products that are in clinical uses to lower cholesterol and lipids and compares these drugs in responses to different ...

Author:

Publisher:

ISBN: 9535127357

Category:

Page:

View: 945

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Cholesterol lowering Therapy

This timely reference reviews the vast body of clinical trial evidence supporting the once controversial view that high levels of serum cholesterol are a major risk factor in coronary heart disease (CHD).

Author: Scott M. Grundy

Publisher: CRC Press

ISBN: 0367399326

Category:

Page: 352

View: 695

DOWNLOAD →

Reveals important new results from clinical trials conducted in Scandinavia, Scotland, Australia, Canada, and the United States. This timely reference reviews the vast body of clinical trial evidence supporting the once controversial view that high levels of serum cholesterol are a major risk factor in coronary heart disease (CHD). The studies presented in Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence promote cholesterol reduction as a highly successful means of preventing heart disease in various populations. Investigates past, current, and upcoming controlled clinical trials of cholesterol-reduction therapies, comparing effects of statins and bile acid sequestrants to triglyceride-lowering drugs and antioxidants. Written by more than 25 distinguished international researchers, Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence highlights historical studies of dietary trials designed to reduce CHD covers tests of HMG CoA reductase inhibitors for patients with and without CHD illuminates CHD risk factors such as diabetes, hypertension, obesity, and smoking explores blood levels of homocysteine and lipoprotein(a) and other recently identified CHD risk factors reviews metabolism of lipoproteins expressed in high (HDL) and low (LDL) density lipoprotein cholesterol and more! Containing over 700 instructive tables, drawings, photographs, and bibliographic citations, Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence is a must-read resource for cardiologists, pharmacologists, and upper-level undergraduate, graduate, and medical school students in these disciplines.

Cholesterol in Atherosclerosis and Coronary Heart Disease

This new book focuses on cholesterol in atherosclerosis and coronary heart disease.

Author: Jean P. Kovala

Publisher: Nova Publishers

ISBN: 159454302X

Category: Science

Page: 264

View: 424

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Cholesterol is a soft, waxy substance found among the lipids (fats) in the bloodstream and in all the body's cells. It's an important part of a healthy body because it's used to form cell membranes, some hormones and is needed for other functions. But a high level of cholesterol in the blood -- hypercholesterolemia -- is a major risk factor for coronary heart disease, which leads to heart attack. Cholesterol and other fats can't dissolve in the blood. They have to be transported to and from the cells by special carriers called lipoproteins. There are several kinds, but the key ones are low-density lipoprotein (LDL) and high-density lipoprotein (HDL) Low-density lipoprotein is the major cholesterol carrier in the blood. If too much LDL cholesterol circulates in the blood, it can slowly build up in the walls of the arteries feeding the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This field is alive with exciting new research in all areas including frontal advances in the areas of managing cholesterol as well as cholesterol lowering drugs. This new book focuses on cholesterol in atherosclerosis and coronary heart disease.

Cholesterol Lowering

This handy practical guide takes this complex subject and puts it into context for the non-specialist.

Author: Jonathan Abrams

Publisher: CRC Press

ISBN: 0340761326

Category: Medical

Page: 160

View: 908

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Over the past decade there has been a revolution in our understanding of hypercholesterolemia and its effect on clinical coronary artery disease. While a number of controversies and unresolved issues remain, the benefit of lowering blood lipid levels and, in particular, LDL cholesterol is firmly established. This handy practical guide takes this complex subject and puts it into context for the non-specialist. Summarizing recent clinical data, it outlines the basis for the current view that aggressive lipid lowering in selected individuals is an imperative in controlling coronary events. Opening with a general and broad introduction to the subject, this is followed by consideration of the biology and pathophysiology of the vascular wall, and a discussion of the basic science that underlies the impact of elevated LDL cholesterol on the function and patho-anatomy of the coronary arteries. Subsequent chapters review practical aspects of lipid management such as what to measure and when, patient selection and the role of diet and lifestyle in disease progression. Presented in a compact format for ease of reference, the general physician, general or office practitioner, trainee doctor and cardiac nurse specialist will find this an invaluable guide to be reached for frequently in the busy clinical setting.