Biomechanics of Cells and Tissues

Each chapter presents a compendium or a review of the original results achieved by authors in the last years. Furthermore, the book also wants to pinpoint the questions that are still open and that could propel future research.

Author: Paola Lecca

Publisher: Springer Science & Business Media

ISBN: 9789400758902

Category: Technology & Engineering

Page: 168

View: 630

DOWNLOAD →

The application of methodological approaches and mathematical formalisms proper to Physics and Engineering to investigate and describe biological processes and design biological structures has led to the development of many disciplines in the context of computational biology and biotechnology. The best known applicative domain is tissue engineering and its branches. Recent domains of interest are in the field of biophysics, e.g.: multiscale mechanics of biological membranes and films and filaments; multiscale mechanics of adhesion; biomolecular motors and force generation. Modern hypotheses, models, and tools are currently emerging and resulting from the convergence of the methods and phylosophycal apporaches of the different research areas and disciplines. All these emerging approaches share the purpose of disentangling the complexity of organisms, tissues, and cells and mimiking the function of living systems. The contributions presented in this book are current research highlights of six challenging and representative applicative domains of phyisical, engineering, and computational approaches in medicine and biology, i.e tissue engineering, modelling of molecular structures, cell mechanics and cell adhesión processes, cancer physics, and physico-chemical processes of metabolic interactions. Each chapter presents a compendium or a review of the original results achieved by authors in the last years. Furthermore, the book also wants to pinpoint the questions that are still open and that could propel the future research.

Biomechanics

The objective of this book remains the same as that stated in the first edition: to present a comprehensive perspective of biomechanics from the stand point of bioengineering, physiology, and medical science, and to develop mechanics ...

Author: Y. C. Fung

Publisher: Springer Science & Business Media

ISBN: 9781475722574

Category: Medical

Page: 568

View: 745

DOWNLOAD →

The objective of this book remains the same as that stated in the first edition: to present a comprehensive perspective of biomechanics from the stand point of bioengineering, physiology, and medical science, and to develop mechanics through a sequence of problems and examples. My three-volume set of Bio mechanics has been completed. They are entitled: Biomechanics: Mechanical Properties of Living Tissues; Biodynamics: Circulation; and Biomechanics: Motion, Flow, Stress, and Growth; and this is the first volume. The mechanics prerequisite for all three volumes remains at the level of my book A First Course in Continuum Mechanics (3rd edition, Prentice-Hall, Inc. , 1993). In the decade of the 1980s the field of Biomechanics expanded tremen dously. New advances have been made in all fronts. Those that affect the basic understanding of the mechanical properties of living tissues are described in detail in this revision. The references are brought up to date.

Biomechanics Trends in Modeling and Simulation

The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues.

Author: Gerhard A. Holzapfel

Publisher: Springer

ISBN: 9783319414751

Category: Technology & Engineering

Page: 316

View: 241

DOWNLOAD →

The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.

Cellular Mechanotransduction

This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals.

Author: Mohammad R. K. Mofrad

Publisher: Cambridge University Press

ISBN: 9781316139479

Category: Technology & Engineering

Page:

View: 780

DOWNLOAD →

'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.

Cardiovascular Solid Mechanics

This text presents a general introduction to soft tissue biomechanics.

Author: Jay D. Humphrey

Publisher: Springer Science & Business Media

ISBN: 9780387215761

Category: Science

Page: 758

View: 431

DOWNLOAD →

This text presents a general introduction to soft tissue biomechanics. One of its primary goals is to introduce basic analytical, experimental and computational methods. In doing so, it enables readers to gain a relatively complete understanding of the biomechanics of the heart and vasculature.

Biomechanics of Soft Tissues

This book is tailored to cover a range of mechanical principles, properties, and applications of soft tissues that have previously been addressed in various journals and "anatomical site-specific" books.

Author: Adil Al Mayah

Publisher: CRC Press

ISBN: 9781351135818

Category: Medical

Page: 188

View: 502

DOWNLOAD →

This book addresses the need of practitioners and researchers in the biomedical sciences to better understand the principles of biomechanics of soft tissue. This book will thoroughly incorporate a number of applications and examples of biomechanics both from an engineering and clinical standpoint. It starts with the fundamental of soft tissues biology and structures. This is followed by providing the basic biomechanical principles such as stress-strain relationship of tissues defining mechanical parameters. In turn, this paves the way for the incorporation of appropriate applications such as radiotherapy, surgery and diagnostics.

Introductory Biomechanics

The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course."--Pub. desc.

Author:

Publisher:

ISBN: OCLC:667094275

Category: Biomechanics

Page: 511

View: 321

DOWNLOAD →

"Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course."--Pub. desc.

Tissue Mechanics

The objective of this text is to describe the nature of the composite components of a tissue, the cellular processes that produce these constituents, the assembly of the constituents into a hierarchical structure, and the behavior of the ...

Author: Stephen C. Cowin

Publisher: Springer Science & Business Media

ISBN: 9780387368252

Category: Technology & Engineering

Page: 682

View: 224

DOWNLOAD →

The structures of living tissues are continually changing due to growth and response to the tissue environment, including the mechanical environment. Tissue Mechanics is an in-depth look at the mechanics of tissues. Tissue Mechanics describes the nature of the composite components of a tissue, the cellular processes that produce these constituents, the assembly of the constituents into a hierarchical structure, and the behavior of the tissue’s composite structure in the adaptation to its mechanical environment. Organized as a textbook for the student needing to acquire the core competencies, Tissue Mechanics will meet the demands of advanced undergraduate or graduate coursework in Biomedical Engineering, as well as, Chemical, Civil, and Mechanical Engineering. Key features: Detailed Illustrations Example problems, including problems at the end of sections A separate solutions manual available for course instructors A website (http://tissue-mechanics.com/) that has been established to provide supplemental material for the book, including downloadable additional chapters on specific tissues, downloadable PowerPoint presentations of all the book's chapters, and additional exercises and examples for the existing chapters. About the Authors: Stephen C. Cowin is a City University of New York Distinguished Professor, Departments of Biomedical and Mechanical Engineering, City College of the City University of New York and also an Adjunct Professor of Orthopaedics, at the Mt. Sinai School of Medicine in New York, New York. In 1985 he received the Society of Tulane Engineers and Lee H. Johnson Award for Teaching Excellence and a recipient of the European Society of Biomechanics Research Award in 1994. In 1999 he received the H. R. Lissner medal of the ASME for contributions to biomedical engineering. In 2004 he was elected to the National Academy of Engineering (NAE) and he also received the Maurice A. Biot medal of the American Society of Civil Engineers (ASCE). Stephen B. Doty is a Senior Scientist at Hospital for Special Surgery, New York, New York and Adjunct Professor, School of Dental and Oral Surgery, Columbia University, New York, NY. He has over 100 publications in the field of anatomy, developmental biology, and the physiology of skeletal and connective tissues. His honors include several commendations for participation in the Russian/NASA spaceflights, the Spacelab Life Science NASA spaceflights, and numerous Shuttle missions that studied the influence of spaceflight on skeletal physiology. He presently is on the scientific advisory board of the National Space Biomedical Research Institute, Houston, Texas.

Biomechanical Modelling at the Molecular Cellular and Tissue Levels

J. D. Humphrey. Cardiovascular Solid Mechanics. Cells, Tissues, and Organs. Springer- Verlag, New York, 2002. J. D. Humphrey. Continuum biomechanics of soft biological tissues. Proc. Need for a Continuum Biochemomechanical Theory 75.

Author: Gerhard A. Holzapfel

Publisher: Springer Science & Business Media

ISBN: 9783211958759

Category: Technology & Engineering

Page: 344

View: 521

DOWNLOAD →

J.D. Humphrey: Need for a Continuum Biochemomechanical Theory of Soft Tissue and Cellular Growth and Remodeling H. Schmid and P.J. Hunter: Multi-scale Modelling of the Heart R.W. Ogden: Anisotropy and Nonlinear Elasticity in Arterial Wall Mechanics G.A. Holzapfel: Arterial Tissue in Health and Disease: Experimental Data, Collagen-based Modeling and Simulation, Including Aortic Dissection.

Biomechanics of Soft Tissue in Cardiovascular Systems

The book is written by leading experts in the field presenting an up-to-date view of the subject matter in a didactically sound manner.

Author: Gerhard A. Holzapfel

Publisher: Springer

ISBN: 9783709127360

Category: Technology & Engineering

Page: 342

View: 253

DOWNLOAD →

The book is written by leading experts in the field presenting an up-to-date view of the subject matter in a didactically sound manner. It presents a review of the current knowledge of the behaviour of soft tissues in the cardiovascular system under mechanical loads, and the importance of constitutive laws in understanding the underlying mechanics is highlighted. Cells are also described together with arteries, tendons and ligaments, heart, and other biological tissues of current research interest in biomechanics. This includes experimental, continuum mechanical and computational perspectives, with the emphasis on nonlinear behaviour, and the simulation of mechanical procedures such as balloon angioplasty.

Data Book on Mechanical Properties of Living Cells Tissues and Organs

This data book presents the original, up-to-date information resulting from the research project, supplemented by some of the important basic data published previously.

Author: Hiroyuki Abe

Publisher: Springer Science & Business Media

ISBN: 9784431658627

Category: Technology & Engineering

Page: 436

View: 700

DOWNLOAD →

A research project entitled Biomechanics of Structure and Function of Living Cells, Tissues, and Organs was launched in Japan in 1992. This data book presents the original, up-to-date information resulting from the research project, supplemented by some of the important basic data published previously. The aim of collecting the information is to offer accurate and useful data on the mechanical properties of living materials to biomechanical scientists, biomedical engineers, medical scientists, and clinicians. The data are presented in graphs and tables (one type of data per page) arranged in an easily accessible manner, along with details of the origin of the material and the experimental method. Together with its two companion volumes, Biomechanics: Functional Adaptation and Remodeling and Computational Biomechanics, the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs is a timely and valuable contribution to the rapidly growing field of biomechanics.

Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System

This book is a comprehensive resource for professionals in the biomedical market, materials scientists and biomechanical engineers, and academics in related fields.

Author: Zhongmin Jin

Publisher: Woodhead Publishing

ISBN: 9780128227626

Category: Technology & Engineering

Page: 632

View: 217

DOWNLOAD →

Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System: Biomaterials and Tissues, Second Edition reviews how a wide range of materials are modeled and applied. Chapters cover basic concepts for modeling of biomechanics and biotribology, the fundamentals of computational modeling of biomechanics in the musculoskeletal system, finite element modeling in the musculoskeletal system, computational modeling from a cells and tissues perspective, and computational modeling of the biomechanics and biotribology interactions, looking at complex joint structures. This book is a comprehensive resource for professionals in the biomedical market, materials scientists and biomechanical engineers, and academics in related fields. This important new edition provides an up-to-date overview of the most recent research and developments involving hydroxyapatite as a key material in medicine and its application, including new content on novel technologies, biomorphic hydroxyapatite and more. Provides detailed, introductory coverage of modeling of cells and tissues, modeling of biomaterials and interfaces, biomechanics and biotribology Discusses applications of modeling for joint replacements and applications of computational modeling in tissue engineering Offers a holistic perspective, from cells and small ligaments to complex joint interactions

Introductory Biomechanics

The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.

Author: C. Ross Ethier

Publisher: Cambridge University Press

ISBN: 9781139461825

Category: Technology & Engineering

Page:

View: 171

DOWNLOAD →

Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.

Biomechanics of Soft Tissues

Quantification of the mechanical properties, either at the tissue or cell level can be useful in cancer diagnosis, ... The migration and differentiation of cells within living tissues are also affected by these biomechanical forces.

Author: Adil Al Mayah

Publisher: CRC Press

ISBN: 9781498766234

Category: Medical

Page: 176

View: 327

DOWNLOAD →

The emerging paradigm of incorporating images and biomechanical properties of soft tissues has proven to be an integral part of the advancement of several medical applications, including image guided radiotherapy and surgery, brachytherapy, and diagnostics. This expansion has resulted in a growing community of medical, science, and engineering professionals applying mechanical principles to address medical concerns. This book is tailored to cover a range of mechanical principles, properties, and applications of soft tissues that have previously been addressed in various journals and "anatomical site-specific" books. Biomechanics of Soft Tissues follows a different approach by offering a simplified overview of widely used mechanical models and measuring techniques of soft tissue parameters. This is followed by an investigation of different medical applications, including: biomechanical aspects of cancerous tumor progressions, radiotherapy treatment, and image guided ultrasound guided interventions. Written by leading scholars and professionals in the field, Biomechanics of Soft Tissues combines engineering and medical expertise, thereby producing an excellent source of information for professionals interested in the theoretical and technological advancements related to soft tissues. The book provides medical professionals with an insight on various modeling approaches, testing techniques, and mechanical characteristics that are frequently used by engineers. Conversely, the presented medical applications provide engineers with a glimpse of amazing medical practices and encourage them to expand their roles in the medical field. Provides a simplified overview of mechanics of soft tissues. Highlights different techniques to measure tissues properties for engineering and medical applications. Contains novel ideas to address roles of mechanics in disease progression and treatment. Presents innovative applications of biomechanics in medical procedures.

Biomechanics and Cells

Describes how mechanical forces interact with a range of living tissue-types at the level of the cell.

Author: Fiona Lyall

Publisher: Cambridge University Press

ISBN: 9780521454544

Category: Medical

Page: 275

View: 978

DOWNLOAD →

Describes how mechanical forces interact with a range of living tissue-types at the level of the cell.

Biomechanics in Oncology

This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ.

Author: Cheng Dong

Publisher: Springer

ISBN: 9783319952949

Category: Medical

Page: 376

View: 866

DOWNLOAD →

This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer

Advances in Biomechanics and Tissue Regeneration

The state-of-the-art, theories and application are presented, making this book ideal for anyone who is deciding which direction to take their future research in this field.

Author: Mohamed Hamdy Doweidar

Publisher: Academic Press

ISBN: 9780128166109

Category: Science

Page: 430

View: 780

DOWNLOAD →

Advances in Biomechanics and Tissue Regeneration covers a wide range of recent development and advances in the fields of biomechanics and tissue regeneration. It includes computational simulation, soft tissues, microfluidics, the cardiovascular system, experimental methods in biomechanics, mechanobiology and tissue regeneration. The state-of-the-art, theories and application are presented, making this book ideal for anyone who is deciding which direction to take their future research in this field. In addition, it is ideal for everyone who is exploring new fields or currently working on an interdisciplinary project in tissue biomechanics. Combines new trends in biomechanical modelling and tissue regeneration Offers a broad scope, covering the entire field of tissue biomechanics Contains perspectives from engineering, medicine and biology, thus giving a holistic view of the field

Plant Biomechanics

For these plants, a biomechanical perspective based on the tissue level of organization is useful and biologically meaningful. ... It forces us to appreciate that cells and tissues are not combined randomly or with equiprobability.

Author: Karl J. Niklas

Publisher: University of Chicago Press

ISBN: 0226586316

Category: Science

Page: 607

View: 922

DOWNLOAD →

In this first comprehensive treatment of plant biomechanics, Karl J. Niklas analyzes plant form and provides a far deeper understanding of how form is a response to basic physical laws. He examines the ways in which these laws constrain the organic expression of form, size, and growth in a variety of plant structures, and in plants as whole organisms, and he draws on the fossil record as well as on studies of extant species to present a genuinely evolutionary view of the response of plants to abiotic as well as biotic constraints. Well aware that some readers will need an introduction to basic biomechanics or to basic botany, Niklas provides both, as well as an extensive glossary, and he has included a number of original drawings and photographs to illustrate major structures and concepts. This volume emphasizes not only methods of biomechanical analysis but also the ways in which it allows one to ask, and answer, a host of interesting questions. As Niklas points out in the first chapter, "From the archaic algae to the most derived multicellular terrestrial plants, from the spectral properties of light-harvesting pigments in chloroplasts to the stacking of leaves in the canopies of trees, the behavior of plants is in large part responsive to and intimately connected with the physical environment. In addition, plants tend to be exquisitely preserved in the fossil record, thereby giving us access to the past." Its biomechanical analyses of various types of plant cells, organs, and whole organisms, and its use of the earliest fossil records of plant life as well as sophisticated current studies of extant species, make this volume a unique and highly integrative contribution to studies of plant form, evolution, ecology, and systematics.