Biological Effects of Dietary Restriction

The influence of quality and quantity of diet regimens (principally, dietary and caloric restriction) on ... More recent advances in assessing the effects of long-term caloric restriction on a host of physiological, biological, ...

Author: Lawrence Fishbein

Publisher: Springer Science & Business Media

ISBN: 9783642581816

Category: Medical

Page: 354

View: 255


How does dietary restriction affect the physiological and biochemical state of laboratory animals? How will the present conclusions affect further research? What are the implications for human health and safety assessment? These are the main questions asked in this book by leading international researchers. After a first look at feeding regimens and diets of laboratory animals, the book elaborates on a variety of age-associated toxicological and pathological endpoints including tumor development. The following sections detail the underlying mechanisms which may induce the broad spectrum of physiological and biochemical changes. This summary of current multidisciplinary research will enhance understanding of the practical applications and implications of dietary restriction.

Exercise Calories Fat and Cancer

J.E.A. Leakey, J.J. Bazare, J.R. Harmon, R.J. Feuers, P.H. Duffy, and R.W. Hart, Effects of caloric restriction on hepatic drug metabolizing enzyme activities in the Fischer-344 rat, in: "Biological Effects of Dietary Restriction," L.

Author: Maryce M. Jacobs

Publisher: Springer Science & Business Media

ISBN: 9781468479539

Category: Medical

Page: 318

View: 609


The American Institute for Cancer Research (AICR) sponsored its second annual conference on nutrition and cancer. The theme was "Exercise, Calories, Fat, and Cancer" and the conference was held September 4-5, 1991 at the Ritz Carlton Hotel in Pentagon City, Virginia. This proceedings volume contains chapters from the platform presentations and abstracts from each poster presentation. Relationships among physical activity, calorie consumption, energy expenditure, dietary fat, and cancer are described in the context of epidemiologic, animal, and in vitro studies. Dietary recommendations to lower cancer risk are based on expanding evidence relating nutrition and cancer. Identification of the precise dietary contribution to disease is complicated by the concurrent genetic and environmental contributions, in addition to the inherent difficulties in gathering and interpreting epidemiologic data. Individual variations in cancer risk are the result of differences in genetic and environmental factors including sources and amounts of calories consumed, metabolism, and energy expenditure. Human and animal studies describing independent and combined influences of exercise, calorie restriction, and dietary fat on carcinogenesis are reported in this volume.

Dietary Restriction

Nutr Cancer 20 : 187-196 Chou NW , Pegram RA , Gao P , Allaben WT ( 1991 ) Effects of caloric restriction on aflatoxin B , metabolism and DNA modification in Fischer 344 rats . In Fishbein L ( ed ) , Biological effects of dietary ...

Author: Ronald W. Hart

Publisher: International Life Sciences Inst

ISBN: CORNELL:31924073938874

Category: Health & Fitness

Page: 430

View: 964


Pancreatic Hormones Advances in Research and Application 2013 Edition

Charles C. Thomas (1988); Yu, 'Modulation of Aging Processes by Dietary Restriction,' Boca Raton: CRC Press (1994); and Fishbein, 'Biological Effects of Dietary Restriction,' Springer, New York (1991). These effects of caloric ...


Publisher: ScholarlyEditions

ISBN: 9781481690966

Category: Medical

Page: 806

View: 505


Pancreatic Hormones—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Pancreatic Hormones—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pancreatic Hormones—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Caloric Restriction A Key to Understanding and Modulating Aging

Chronic caloric restriction in old female mice: changes in circadian rhythms of physiological and behavioral variables. In: L. Fishbein (Ed), Biological Effects of Dietary Restriction, (pp. 245–263). Berlin: Springer-Verlag.

Author: E.J. Masoro

Publisher: Elsevier

ISBN: 9780080528427

Category: Medical

Page: 192

View: 732


For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages. What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.

Handbook of the Biology of Aging

Genetic response to dietary restriction Several methods of environmental manipulation are known to impact lifespan. ... is directed at understanding the biological processes underlying the beneficial effects of dietary restriction.

Author: Nicolas Musi

Publisher: Academic Press

ISBN: 9780128162835

Category: Education

Page: 468

View: 875


Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more. Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control Examines the diverse research being conducted in the study of the biology of aging

Scientific Directory and Annual Bibliography

Behavioral and neurobiological effects of dietary restriction in aged rodents . In : Fishbein L , ed . Biological effects of dietary restriction . Berlin : Springer , 1991 ; 157-71 . 3081. Ingram DK . Effects of dietary restriction on ...

Author: National Institutes of Health (U.S.)


ISBN: MINN:31951P010904001

Category: Biochemistry

Page: 550

View: 883


Each issue lists papers published during the preceding year.

Nutrition and Immunology

Witt, W. M., Sheldon, W. G., and Thurman, J. D., 1991, Pathological endpoints in dietary restricted rodents—Fischer 344 rats and B6C3F1 mice, in: Biological Effects of Dietary Restriction (L. Fishbein, ed.), Springer-Verlag, Berlin, pp.

Author: D.M. Klurfeld

Publisher: Springer Science & Business Media

ISBN: 9781461529002

Category: Technology & Engineering

Page: 358

View: 391


Historically, nutrient deficiencies have been of greater concern than dietary excess. However, along with the realization that deaths due to certain diseases are more prevalent in affluent countries came the conclusion that nutritional excess is of equal or in greater concern in many nations. Because immunologic reactions may play a role development of both cancer and atherosclerosis, better understanding of these interre lated phenomena may lead to innovative ideas for control of these diseases. There has been considerable interest in the role various nutrients may play in regulating immunologic responses. This has been especially true as a possible mecha nism by which fat modulates growth of tumors in animals. Likewise, deficiency or excess of a number of other individual nutrients have been linked to altered immune responses. This volume of Human Nutrition-A Comprehensive Treatise details the effects of a number of nutrients on immunity. The first chapter covers questionable and fraudu lent claims linking nutrition and immunity. The next chapter examines several aspects of food allergy. Ensuing chapters focus on specific nutrients such as fat, cholesterol, arginine, vitamins C, A, and E, carotenoids, flavonoids, zinc, iron, copper, and sele nium. There are two chapters on total energy intake affecting immune response, one examining protein-energy malnutrition and the other describing the effects of food restriction in otherwise healthy animals.

Current Perspectives on Nutrition and Health

43 Fernandas G , Khare A , Langamere S , Yu B , Sandberg L , Fredricks B. Effect of food restriction and aging on immune cell fatty acids , functions and oncogene expression in SPF Fischer ... Biological effects of dietary restriction .

Author: Royal Society of Canada

Publisher: McGill-Queen's Press - MQUP

ISBN: 0773517243

Category: Health & Fitness

Page: 340

View: 508


The contributors explore recent findings on disease patterns, health maintenance, and dietary approaches to reducing the risk of chronic disease. Internationally known experts provide valuable new information on the influence of diet on heart disease, cancer, hypertension, kidney disease, diabetes, obesity, and osteoporosis. As well, they examine recent developments in nutrition research in Britain and other European countries and discuss priorities for nutrition research in Canada as set forth in a report recently released by the Ministry of Health. Current Perspectives on Nutrition and Health will be a valuable resource for health care professionals, food producers, governments, and the general public.

The Mouse in Biomedical Research

Physiological assays for biological age in mice: relationship of collagen, renal function and longevity. Exp Aging Res 9,245–251. Harrison, D.E., Archer, J.R. (1987). Genetic effects on responses to food restriction in aging mice.


Publisher: Elsevier

ISBN: 0080469078

Category: Science

Page: 816

View: 800


Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.