ABC Transporters in Microorganisms

This concise volume describes the latest, up-to-date theory, methodology, and applications of ABC transporters in microorganisms.

Author: Alicia Ponte-Sucre

Publisher: Caister Academic Press Limited

ISBN: 1904455492

Category: Science

Page: 0

View: 268


This concise volume describes the latest, up-to-date theory, methodology, and applications of ABC transporters in microorganisms. The topics include the structure, physiology, and evolution of ABC transporters, as well as their special characteristics in specific microorganisms, including bacteria, yeast, trypanosomes, and malaria parasites. In particular, the book describes the most recent research and innovations relative to the role of ABC transporters in the design of strategies to circumvent drug resistance in microorganisms. Each chapter comprises an exhaustive review of the particular topic and provides insights into the future of the field, both from the scientific and clinical perspective. A skillful selection of topics and a panel of acknowledged experts ensure that this concise volume will be of exceptional importance to everyone involved in DNA superfamily research, as well as scientists interested in microbial physiology and multidrug resistance. It is essential reading for anyone involved in this field, and it is a recommended volume for all microbiology laboratories.

ABC Transporters and Multidrug Resistance

In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.

Author: Ahcène Boumendjel

Publisher: John Wiley & Sons

ISBN: 9780470495124

Category: Medical

Page: 480

View: 336


A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Plant ABC Transporters

EMBO J 31:2965–2980 Higgins CF (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8:67–113 Higgins CF, Gottesman MM (1992) Is the multidrug transporter a flippase? Trends Biochem Sci 17:18–21 Higgins CF, ...

Author: Markus Geisler

Publisher: Springer

ISBN: 9783319065113

Category: Science

Page: 331

View: 368


This book is devoted to the fascinating superfamily of plant ATP-binding cassette (ABC) transporters and their variety of transported substrates. It highlights their exciting biological functions, covering aspects ranging from cellular detoxification, through development, to symbiosis and defense. Moreover, it also includes a number of chapters that center on ABC transporters from non-Arabidopsis species. ABC proteins are ubiquitous, membrane-intrinsic transporters that catalyze the primary (ATP-dependent) movement of their substrates through biological membranes. Initially identified as an essential aspect of a vacuolar detoxification process, genetic work in the last decade has revealed an unexpectedly diverse variety of ABC transporter substrates, which include not only xenobiotic conjugates, but also heavy metals, lipids, terpenoids, lignols, alkaloids and organic acids. The discovery that members of the ABCB and ABCG family are involved in the movement of phytohormones has further sparked their exploration and provided a new understanding of the whole family. Accordingly, the trafficking, regulation and structure-function of ABCB-type auxin transporters are especially emphasized in this book.

Efflux Mediated Antimicrobial Resistance in Bacteria

Vetrivel U, Subramanian G (2014) Importance of ABC transporters in different tissues. Drug Metabol Drug Interact 29:65–66. doi:10.1515/dmdi-2014-0016 74. Higgins CF (1992) ABC transporters: from microorganisms to man.

Author: Xian-Zhi Li

Publisher: Springer

ISBN: 9783319396583

Category: Medical

Page: 848

View: 179


This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.

ABC Proteins

From Bacteria to Man I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins. Goldman, B.S., Gabbert, K.K. and Kranz ... Higgins, C.F. (1992) ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8, 67–113.

Author: I Barry Holland

Publisher: Elsevier

ISBN: 9780080481876

Category: Science

Page: 530

View: 327


ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Phylogeny and Evoloution of ABC Transporters Fundamental Aspects of the Mechanism of Action of ABC Transporters Prokaryote ABC Transporters Non-Mammalian Transporters Multidrug Transporters ABC Transporters, Physiological Roles and Human Disease Full color throughout

Biotechnological Applications of Extremophilic Microorganisms

5.3.4 The “leaky” mutant procedure (exploiting a mutant which excretes ectoine into the medium) Microorganisms do not rely entirely ... Unlike the ABC transporters that are fuelled by ATP hydrolysis, TRAP-T are secondary transporters.

Author: Natuschka M. Lee

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 9783110424331

Category: Nature

Page: 424

View: 569


This book provides a broad overview how extremophiles can be used in biotechnology, including for the production and degradation of compounds. It reviews various recent discoveries and applications related to a large variety of extremophiles, considering both prokaryotes as well as eukaryotes.

Encyclopedia of Cancer

Other members of the ABC-transporter family couple ATP binding and hydrolysis to the control of translation or >DNA repair. ... Lage H (2003) ABC-transporters: implications on drug resistance from microorganisms to human cancers.

Author: Manfred Schwab

Publisher: Springer Science & Business Media

ISBN: 9783540368472

Category: Medical

Page: 3307

View: 428


This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

ABC Transporters Biochemical Cellular and Molecular Aspects

Multicomponent Exporters Multicomponent ABC transporters that export a variety of substrates have been identified in both eukaryotic and prokaryotic organisms . Although not characterized as well as many of the bacterial permeases ...

Author: John N. Abelson

Publisher: Gulf Professional Publishing

ISBN: 0121821935

Category: Science

Page: 902

View: 794


The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchersin all fields of life sciences. Prokaryotic ABC Transporters Eukaryotic ABC Transporters Nonmammalian ABC Transport Systems Mammalian P-Glycoproteins Multidrug Resistance Associated Protein Cystic Fibrosis Transmembrane Conductance Regulator Sulfonylurea Receptor Intracellular ABC Transporters

Transporters as Drug Carriers

resistance and ABC transporters in parasitic protozoa. ... Wolfger, H., Mamnun, Y.M., and Kuchler, K. (2001) Fungal ABC proteins: pleiotropic drug resistance, ... Higgins, C.F. (1992) ABC transporters: from microorganisms to man.

Author: Gerhard F. Ecker

Publisher: John Wiley & Sons

ISBN: 352762743X

Category: Science

Page: 449

View: 209


This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion. As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

Unusual Secretory Pathways From Bacteria to Man

It could well be that another molecule, likely however to be an ABC transporter, and sharing the ABC1 ... Bacterial periplasmic transport system: structure, mechanism and evolution. ... ABC transporters: from microorganisms to man.

Author: Karl Kuchler

Publisher: Springer Science & Business Media

ISBN: 9783662225813

Category: Science

Page: 230

View: 794


This book constitutes the first comprehensive discussion and collection of facts and functions of unconventional secretory pathways, some of which are of importance in human disease and pathology. The function of ABC transporters in these processes is also discussed. This comparison of common aspects and similarities in all living cells - from bacteria to man - is an excellent reference book with "textbook" character.